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Applications of Shenkang injection in preparation of medicaments used for prevention or treatment of renal toxicty caused by radiotherapy or chemotherapy

A technology of Shenkang injection and nephrotoxicity, applied in the field of Shenkang injection, can solve the problems of toxicity, kidney, and large toxic and side effects of anti-tumor drugs.

Active Publication Date: 2013-09-11
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Long-term use of anti-tumor drugs in cancer patients can also cause renal toxicity
Moreover, the curative effect of most antineoplastic drugs is directly proportional to the dosage of the drug, and severe nephrotoxicity will be manifested if taken in large quantities or for a long time each time.
Due to the large toxic and side effects of antineoplastic drugs, the choice of dosage is limited in clinical application

Method used

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  • Applications of Shenkang injection in preparation of medicaments used for prevention or treatment of renal toxicty caused by radiotherapy or chemotherapy
  • Applications of Shenkang injection in preparation of medicaments used for prevention or treatment of renal toxicty caused by radiotherapy or chemotherapy
  • Applications of Shenkang injection in preparation of medicaments used for prevention or treatment of renal toxicty caused by radiotherapy or chemotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1 Take 700 g of rhubarb and 600 g of Danshen, extract them with water three times, combine the water extracts, concentrate, and go through two alcohol precipitations and gelatin detanning, take the supernatant, filter and clarify, recover ethanol, add water for injection, refrigerate, Concentrate the supernatant, add 95% ethanol, let it stand, recover the ethanol, add water for injection again; take the supernatant, add activated carbon, adjust the pH value, and sterilize to obtain rhubarb and salvia miltiorrhiza extracts, set aside; take 800g safflower 1500g of Radix Astragali, after 3 times of water extraction, combined the water extract, concentrated, after 2 times of alcohol precipitation, recovered ethanol, added water for injection again, refrigerated, took the supernatant, added activated carbon, filtered, refrigerated, adjusted pH value, Sterilize to obtain safflower and astragalus extracts, and set aside; combine the above-mentioned rhubarb and salvia ex...

Embodiment 2

[0011] The proportioning of raw materials is: rhubarb 1000g, salvia miltiorrhiza 1000g, safflower 900g, astragalus 3000g, and the preparation method is the same as that in Example 1.

Embodiment 3

[0013] The proportioning of raw materials is: rhubarb 1500g, salvia miltiorrhiza 1000g, safflower 1000g, astragalus 2000g, and the preparation method is the same as that in Example 1.

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Abstract

The invention provides applications of Shenkang injection in preparation of medicaments used for prevention or treatment of kidney toxicity caused by radiotherapy or chemotherapy. The injection comprises, by weight, the following drug ingredients: 7 to 15 portions of rheum officinale, 6 to 15 portions of red sage root, 8 to 15 portions of safflower and 15 to 45 portions of radix astragali. An experiment confirms that the Shenkang injection of the invention mayhelp to decrease serum creatinine and urea nitrogen content of animals after radiotherapy or chemotherapy, and decrease urine protein content of rats after chemotherapy. Clinical experiments confirm that the Shenkang injection has substantial effects in treatment of patients with renal toxicty caused by radiotherapy or chemotherapy.

Description

technical field [0001] The invention relates to a new application of Shenkang injection. That is to say, Shenkang Injection can prevent and treat nephrotoxicity caused by radiotherapy and chemotherapy, and cooperate with conventional radiotherapy and chemotherapy to treat tumors, which can reduce the possible toxic and side effects during the treatment process. It belongs to the field of medical use. Background technique [0002] Conventional methods used to treat tumor diseases have certain toxic effects on many organs, especially kidney toxicity, which has attracted more and more attention. Studies have shown that in the radiation treatment of tumor diseases, the radiation dose is 1000-2000 rads, and the kidneys will not produce persistent pathological abnormalities within 2-3 weeks; when the dose is 2300-2500 rads, it will be visible after 4-5 weeks Histopathological changes in the early stage of the kidney are mostly manifested as proliferation of glomerular endothelia...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61P13/12
Inventor 曹凤君吕延英詹芳王光建赵兴王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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