Egg yolk antibody microcapsule for resisting hand-foot-and-mouth disease, and preparation method thereof

Abstract

The invention provides an egg yolk antibody microcapsule for resisting a hand-foot-and-mouth disease, also provides a preparation method of the egg yolk antibody microcapsule. The egg yolk antibody microcapsule for resisting the hand-foot-and-mouth disease, which is provided by the invention, effectively reduces the deactivation rate of an egg yolk antibody, improves the adhesion release performance to enterocyte, is good in stability, safe and free of side effect, and does not generate drug resistance. According to the technical scheme, the egg yolk antibody microcapsule for resisting the hand-foot-and-mouth disease is composed of a capsule core and a capsule membrane, wherein the capsule core refers to spherical particles of calcium carbonate containing the egg yolk antibody and two polypeptides with opposite charges are alternately absorbed many time and coated so as to form the capsule membrane. The preparation method orderly comprises the following steps of: 1) preparing egg yolk antibody solution; 2) preparing a spherical template of calcium carbonate containing the egg yolk antibody; 3) preparing nuclear membrane microspheres containing the egg yolk antibody; and 4) removing the core spherical template of calcium carbonate. The egg yolk antibody microcapsule and the preparation method belong to the technical field of a biological medicine.

Description

technical field [0001] The invention discloses a yolk antibody microcapsule, specifically an anti-hand, foot and mouth disease yolk antibody microcapsule. The invention also discloses a preparation method of the yolk antibody microcapsule, which belongs to the technical field of biomedicine. Background technique [0002] Hand, foot and mouth disease is an acute infectious disease of infants and young children caused by enterovirus. It spreads rapidly and has a wide range, seriously affecting the healthy growth of infants and young children. The main pathogenic virus is enterovirus 71 (EV71), which is transmitted through the oral cavity and replicates and spreads in the intestinal tract. At present, a vaccine against hand, foot and mouth disease has not been successfully developed. The clinical drugs mainly include antiviral drugs, such as acyclovir, valacyclovir, and ribavirin, which are highly effective and broad-spectrum antiviral drugs, which can significantly shorten fev...

AI Technical Summary

Problems solved by technology

Since the HFMD virus replicates and spreads in the intestinal tract, it needs to carry the antibody to the intestinal tract, but as an oral protein drug, it is easily damaged by gastric acid and pepsin, which reduces the antiviral activity of the antibody

However, traditional enteric-coated capsules are not suitable for infants and young children, and the mechanical strength during the preparation process can easily inactivate proteins

Images