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Application of P110 delta mutational inactivated mouse model

A mouse model, 1.P110 technology, applied in veterinary surgery, veterinary instruments, preparations for in vivo experiments, etc., can solve the problem of not finding an ideal animal model

Inactive Publication Date: 2013-09-25
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0008] However, except for apoE mice, no similar ideal animal models have been found for other diseases of the cardiovascular system.

Method used

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  • Application of P110 delta mutational inactivated mouse model
  • Application of P110 delta mutational inactivated mouse model
  • Application of P110 delta mutational inactivated mouse model

Examples

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Embodiment Construction

[0023] The present invention will be further described below in conjunction with the examples, but not limited thereto.

[0024] 1. Overall observation of p110δ mutant inactivation mice

[0025] In order to further study the feasibility of p110δ-mutant mice as a specific induced aneurysm model, we conducted a systematic analysis of the mice and found that the overall appearance of the mice was similar to that of ordinary C57 / There is no significant difference in B6J mice, and there is no obvious defect in the development process, and its homozygous fecundity is slightly lower than that of ordinary mice; the measurement results of arterial blood pressure are not significantly different from those of ordinary C57 mice; the expression of P110δ protein is the same as that of wild mice; lipid kinase Inactivation, the IA PI3K activity of thymocytes, mature B cells, and T cells is reduced by 30% to 50% compared with normal conditions. HE staining and morphological analysis of impor...

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Abstract

The invention discloses an application of a P110 delta mutational inactivated mouse model, which comprises application of P110 delta mutational inactivated mouse in research of aneurysm occurrence mechanism and / or screening drugs for treating aneurysm. According to the application provided by the invention, tectology and molecular biology methods are symmetrically adopted to determine the vascular wall of the P110 delta mutational inactivated mouse has certain pathological damage, which is mainly characterized by endothelial cells apoptosis, smooth muscle cell decrease and collagen and elastic fiber ingredient reduction, and the raise of the cell factors and the damage characteristics of the vascular wall are very close to the typical characteristics of aneurysm, so that the P110 delta mutational inactivated mouse can be used as an ideal model for the research of initial stage drug target and mechanism of the aneurysm.

Description

technical field [0001] The present invention relates to the application of P110δ mutation inactivation mouse model. Background technique [0002] Aneurysm is a common clinical vascular disease with high lethality. Occur in all parts of the aorta, especially abdominal aortic aneurysm is more common. Its onset is insidious, it is difficult to diagnose in the early stage, and it develops progressively. Most patients have ruptured aneurysm and died before admission. However, patients who can be admitted to hospital for diagnosis often have a tendency to rupture at the lesion. In clinical practice, only surgical methods can be used to reduce the aneurysm. The risk of tumor rupture, there is currently no effective drug available for treatment. [0003] The pathogenesis of aneurysm is complex, and it is mainly considered as a chronic inflammatory vascular disease. Its pathological features mainly include significant loss or rupture of the elastic membrane in the vessel wall, a l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K33/14A61D1/00
Inventor 王丽京郑凌云何晓东李卫东邢丽英
Owner GUANGDONG PHARMA UNIV
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