Preparation method and equipment of a degradable tissue engineering three-dimensional scaffold

Abstract

The invention discloses a method for preparing a degradable tissue engineering three-dimensional support and an electrostatic spinning device for machining the three-dimensional support. The electrostatic spinning device mainly comprises a high voltage power source, a computer, a precise liquid feeding system with a microscale liquid feeding pump, a metal injector head, an X-Y precise carrying platform, a receiving board, a CMOS vidicon and a microscope stage. The electrostatic spinning device can machine the tissue engineering three-dimensional support which is high in porosity, good in mechanical property and biocompatibility, controllable in degradation rate and capable of suspending on a liquid level. The method is simple and the whole process is easy to carry out.

Description

technical field [0001] The invention relates to the technical field of tissue engineering and micro-nano manufacturing, in particular to a method for preparing a degradable tissue engineering three-dimensional scaffold and an electrospinning device for manufacturing the three-dimensional scaffold. Background technique [0002] Human tissue damage and defect will lead to dysfunction. The traditional repair method is autologous tissue transplantation. Although it can achieve satisfactory curative effect, it is at the expense of autologous healthy tissue, which will lead to many complications and additional damage; For organ failure, drug treatment and temporary replacement therapy can save the lives of some patients, but the source of donor organs is extremely limited, and immunosuppressants need to be used for a long time due to immune rejection, and the complications caused by this are sometimes fatal. To solve these problems, tissue engineering is proposed to restore, maint...

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Problems solved by technology

[0005] Some three-dimensional scaffolds have been used clinically, but there are still problems with existing products: 1. The mechanical properties of the scaffolds are poor, and they are prone to deformation or fracture; 2. The degradation cycle of the scaffolds is a fixed value, which is only suitable for tissue engineering specific 3. The porosity of the obtained three-dimensional scaffold is difficult to control, and the randomness is relatively large

Different types of receiving devices can obtain three-dimensional scaffolds with different structures, but they all face the same problem: 1. The electrospinning process is affected by many factors, and there is great instability; 2. The electrospinning process cannot be automated and visualized ; 3, the prepared three-dimensional scaffold structure is single, there are certain limitations in the application of tissue engineering

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