A kind of freeze-dried powder injection for chicken embryo polysaccharide injection and preparation method thereof

Abstract

The invention relates to a freeze-dried powder injection for injection of chick embryo polysaccharide and a preparation method thereof. The freeze-dried powder injection comprises chick embryo polysaccharide and a freeze-dried excipient in a weight ratio of 1-10:90-99. The selected excipient is one or more from amino acids and salts, and has no influence on quantitative analysis of chick embryo polysaccharide. The preparation method is as follows: dissolving the chick embryo polysaccharide in water, adding active carbon for decolorization, filtering and decarbonizing, adding and dissolving the excipient, adjusting the pH value, adding active carbon, filtering and packing; cooling to 46-40 DEG C within 0.5 h, insulating and freezing for 3 h, vacuumizing to 7Pa, heating to -20 to -16 DEG C in 6-8 h at a constant speed, keeping for 1-2 h, then heating to -3-5 DEG C in 5-7 h at a constant speed, then heating to 35 DEG C in 5 h at a constant speed and insulating for 3 h. The powder injection prepared by the method of the invention has advantages of accurate dose, stable quality and high purity.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a freeze-dried powder for injection of polysaccharide extracted from chicken embryos and a preparation method thereof. Background of the invention [0002] Cancer is one of the major diseases that seriously affect human health and threaten human life. The report of the World Health Organization shows that in 2008, there were about 12.7 million new cancer patients and 7.6 million cancer deaths in the world, especially in developing countries, where the number of new cancer cases reached 56%. It is estimated that by 2020, the global cancer incidence The rate will increase by 50%, that is, 15 million new cancer patients will be added every year. Not only that, the number of deaths from cancer is also rising rapidly around the world, and this number may increase to 13.2 million in 2030. Therefore, the research on cancer treatment drugs is related to the vital interests of...

AI Technical Summary

Problems solved by technology

Radiotherapy and chemotherapy also have a killing effect on normal cells, which are characterized by poor specificity and huge side effects. While killing tumor cells, they also greatly interfere with the normal functions of the body, which is not conducive to long-term medication

Due to the lack of effective control methods for cancer, the prognosis of patients is extremely poor

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