Extraction technology of pongamia pinnata extract and use of the pongamia pinnata extract in treatment on liver injury

An extraction process and extract technology, applied in the field of biopharmaceuticals, can solve problems such as no scientific research reports, achieve significant preventive effects, reduce liver tissue edema, and reduce liver coefficient effects

Inactive Publication Date: 2013-10-02
陈乃宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The folk application of water pampas to treat acute and chronic viral hepatitis and jaundice has a long history, and it is believed that the effect is good, but there is no systematic and in-depth scientific research report

Method used

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  • Extraction technology of pongamia pinnata extract and use of the pongamia pinnata extract in treatment on liver injury
  • Extraction technology of pongamia pinnata extract and use of the pongamia pinnata extract in treatment on liver injury
  • Extraction technology of pongamia pinnata extract and use of the pongamia pinnata extract in treatment on liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Using the D-GalN / LPS-induced acute liver injury model in mice, the effects of active extracts Gea and Yea on liver injury were observed through serum liver function indicators, liver tissue biochemical indicators, and pathological tissue sections.

[0041] experimental method

[0042] 1. Materials and methods

[0043] 1.1 Drugs

[0044] Extracts Gea and Yea were provided by Beijing Xuanwu Hospital; Bicyclol was purchased from China Institute for the Control of Pharmaceutical and Biological Products, batch number: 101044-201001; D-Galactosamine (D-GalN) was purchased from Debao Biochemical Equipment Co., Ltd. Provided, batch number: 20110406; lipopolysaccharide (LPS), provided by SIGMA Company, batch number: 20110523.

[0045] 1.2 Experimental animals

[0046] C57BL / 6 mice, male, weighing 18-22g, SPF grade, Gea experimental part was purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., quality certificate number SCXK (Beijing) 2009-0...

Embodiment 2

[0095] Example 2 By preparing a mouse model of common bile duct ligation to simulate human obstructive jaundice liver injury, the mice were administered intragastrically with extracts Gea and Yea, and then performed common bile duct ligation to explore the effect of extract Gea and Yea on common bile duct ligation. Effects on serum biochemical indexes and liver histopathological structure in rats.

[0096] experimental method:

[0097] 1. Materials and methods

[0098] 1.1 Drugs

[0099] Extracts Gea and Yea were provided by Beijing Xuanwu Hospital; Yinzhihuang Oral Solution was provided by Beijing Shuanghe High-Tech Natural Medicine Co., Ltd., batch number: 272451.

[0100] 1.2 Experimental animals

[0101] C57BL / 6 mice, male, weighing 18-22 g, SPF grade, were purchased from Speiford (Beijing) Experimental Animal Technology Co., Ltd., quality certificate number SCXK (Beijing) 2011-0004. The animals were kept in a clean animal room, the ambient temperature and relative hu...

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Abstract

The invention relates to an extraction technology of pongamia pinnata extract and a use of the pongamia pinnata extract in treatment on the liver injury. The extraction technology is effectively used for researching a drug for treating the liver injury. Pongamia pinnata has a high medicinal value and root, leaves, fruits and seeds of pongamia pinnata have medicinal effects. Through the ages, in a civil field, pongamia pinnata is used for treating acute and chronic viral hepatitis and jaundice and has good effects. An effective ingredient is a Gea-Yea mixture separated from pongamia pinnata. The Gea and Yea extract can obviously improve a survival rate of a mice having a D-GalN / LPS-induced acute liver injury, can reduce liver coefficients of a mice having obstructive jaundice, can reduce ALT, AST, LDH and TBIL levels of serum, can reduce MDA and NO content of liver tissue, can relieve pathological symptoms such as necrosis, degeneration and inflammatory infiltration of liver tissue and has obvious prevention and control effects. The extraction technology is simple, economic and practical. The Gea-Yea mixture has obvious effects of improving all indexes of the liver injury, has good treatment effects and has a good application prospect.

Description

Technical field: [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to an extraction process for extracting Gea and Yea from plant pumella, and its application in the process of liver injury. Background technique: [0002] With the advancement of society and changes in people's lifestyles, liver diseases such as viral hepatitis, alcoholic liver disease, drug-induced liver injury, and autoimmune liver disease are becoming more and more common in daily life and have become thorny problems that seriously endanger human health. question. Acute liver failure due to liver injury accounts for about half of all types of acute and chronic liver diseases. Therefore, drugs for the treatment of liver injury have attracted more and more attention. The drugs used clinically to treat liver diseases mainly include antiviral drugs, immunomodulatory drugs, and liver-protecting drugs, etc. There are many types and different efficacy. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P1/16
Inventor 陈乃宏
Owner 陈乃宏
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