Developing foam hardening agent for treating venous malformations and preparation method thereof

Abstract

The invention discloses a developing foam hardening agent for treating venous malformations. The developing foam hardening agent comprises two effective ingredients, namely, polycinnamyl alcohol and ultravist, in a volume ratio of 2:1. A preparation method of the developing foam hardening agent specifically comprises the following steps of: extracting the polycinnamyl alcohol and the ultravist using by using a syringe according to a formula ratio, shaking and mixing up uniformly, extracting sterile air by using another syringe, connecting the two syringes by using a medicinal three-way valve, and injecting front and back for multiple times according to a Tessari method so as to mix the polycinnamyl alcohol and the ultravist into uniform and stable foams, wherein the volume ratio of the polycinnamyl alcohol to the sterile air is 1:4. According to the preparation method, a hardening agent, namely, a polycinnamyl alcohol injection, and a contrast agent, namely, the ultravist, are mixed up according to appropriate ratio and prepared into a foam hardening agent, the foam hardening agent is more stable when being compared with a hardening agent which is prepared from polycinnamyl alcohol and air merely, and the foam hardening agent is injected into venous malformation lesion in a partial puncture mode under the mediation of DSA (Digital Subtraction Angiography), so that precision, visualization and idealization in a curative effect are achieved.

Description

technical field [0001] The invention relates to a foam sclerosant, in particular to a developing foam sclerosant for treating venous malformations and a preparation method thereof. Background technique [0002] In 1993, Cabrera pioneered the use of foam sclerosing agent to treat venous malformation, and the effect was remarkable, which opened up a new method for the treatment of venous malformation. The incidence of venous malformation in the head and neck is about 40%. Due to the special anatomical location, it is difficult to completely remove it by surgical methods. Foam sclerotherapy is simple, convenient, less expensive, less painful for patients, less risky, and has remarkable curative effect. It is now the first choice for the treatment of head and neck venous malformations. [0003] A variety of imaging methods, including color Doppler ultrasound and digital subtraction angiography (DSA), have been applied to foam sclerotherapy, that is, the visual treatment of veno...

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Problems solved by technology

However, due to the complex structure of the lesion, this method cannot guarantee that the contrast agent is completely replaced by the foam sclerosing agent, and there may be incomplete treatment or the foam overflows the lesion cavity and enters the normal blood circulation to form a gas embolus, resulting in life-threatening complications such as pulmonary embolism. disease

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