Synthetic method of 3-(phenylmethyl)-5-(2-hydroxyethyl)-4-methyl-thiazoline chloride

A technology of methylthiazoline chloride and a synthetic method, applied in directions such as organic chemistry, can solve problems such as low product yield, complicated reaction steps and the like

Inactive Publication Date: 2013-10-16
BENGBU COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The synthesis method of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazoline chloride provided by the prior art has complicated reaction steps and low product yield

Method used

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  • Synthetic method of 3-(phenylmethyl)-5-(2-hydroxyethyl)-4-methyl-thiazoline chloride

Examples

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Embodiment 1

[0019] A kind of synthetic method of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazoline chloride, comprising the following steps:

[0020] (1) Preparation of thioformamide: Take 100 parts by weight of formamide and add it to a reaction kettle with a stirring and cooling device, slowly add 55 parts by weight of phosphorus pentasulfide under stirring, control the temperature at 35°C, and add the time Control it at 1.5h, continue to react for 2h after the feeding, the reaction solution after the reaction is extracted three times with dichloromethane, each time the amount of dichloromethane is 50 parts by weight, and the extract is thioformamide solution;

[0021] (2) Preparation of 4-methyl-5-(2-hydroxyethyl)-thiazole: Take 100 parts by weight of the thioformamide solution prepared in step (1) and add it to a reaction kettle with a stirring and heating device , add 150 parts by weight of 3-chloro-3-acetylpropanol under stirring, then heat up to boiling reflux state, react for 5h and ...

Embodiment 2

[0026] A kind of synthetic method of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazoline chloride, comprising the following steps:

[0027] (1) Preparation of thioformamide: Take 100 parts by weight of formamide and add it to a reaction kettle with a stirring and cooling device, slowly add 55 parts by weight of phosphorus pentasulfide under stirring, control the temperature at 30°C, and add the time Control at 2h, continue to react for 2.5h after the addition, the reaction solution after the reaction is extracted three times with dichloromethane, each time the amount of dichloromethane is 50 parts by weight, and the extract is thioformamide solution;

[0028] (2) Preparation of 4-methyl-5-(2-hydroxyethyl)-thiazole: Take 100 parts by weight of the thioformamide solution prepared in step (1) and add it to a reaction kettle with a stirring and heating device , add 150 parts by weight of 3-chloro-3-acetylpropanol under stirring, then heat up to boiling reflux state, react for 6 hours a...

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Abstract

The invention provides a synthetic method of 3-(phenylmethyl)-5-(2-hydroxyethyl)-4-methyl-thiazoline chloride. In the method, 3-chloro-3-acetyl propanol, formamide, phosphorus pentasulfide and benzyl chloride is used as a raw material and acetonitrile is used as a solvent. The synthetic method comprises the following processes: preparing methanethioamide, preparing 4-methyl-5-(2-hydroxyethyl)-thiazole, synthesizing 3-phenylmethyl-5-(2 -hydroxyethyl)-4-methyl-thiazoline chloride, refining and drying. The preparation method provided by the invention has less reaction steps, a mild reaction condition, and high product yield.

Description

technical field [0001] The invention relates to a synthesis method of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazoline chloride. Background technique [0002] 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazoline chloride can be used as a catalyst in organic synthesis, it can increase aliphatic aldehydes and heterocyclic aldehydes to unsaturated ketones, nitriles and ester on. Its structural formula is [0003] The synthesis method of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazoline chloride provided by the prior art has relatively complicated reaction steps and low product yield. Contents of the invention [0004] The technical problem to be solved in the present invention is to provide a synthetic method of 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazoline chloride, which can be used to prepare 3- Benzyl-5-(2-hydroxyethyl)-4-methylthiazoline chloride, and the method provided by the invention has fewer reaction steps, mild reaction conditions and high product yield. [0005] In o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D277/24
Inventor 郑桂富万海涛叶欢偶德馨
Owner BENGBU COLLEGE
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