Application of hydrophobic glucan in preparation of curcumin solubilizing agent and utilization method of hydrophobic glucan
A technology of dextran and hydrophobicity, which is applied in the field of solubilizers for the preparation of curcumin by hydrophobic dextran, which can solve the problems of poor absorption, photodecomposition, instability, etc., achieve good solubilization effect and improve water solubility Effect
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Embodiment 1
[0030] Preparation of oat dextran hydrolyzates with different molecular weights:
[0031] (1) Preparation of molecular weight 11.9×10 4 g / mol oat dextran hydrolyzate: Stir the oat dextran with a concentration of 1 g / L at 80°C for 2 hours, then cool it to 25°C with running water and filter it with a Buchner funnel to collect the liquid, then Add hydrochloric acid until the final concentration of hydrochloric acid is 6×10 -3 M, and then hydrolyzed at 48°C for 10 minutes, and finally neutralized the hydrolyzate with 2M sodium hydroxide, cooled to 25°C under flowing water, and obtained a molecular weight of 11.9×10 4 g / mol oat glucan hydrolyzate.
[0032] (2) Preparation of molecular weight 7.3×10 4 g / mol oat dextran hydrolyzate: Stir the oat glucan with a concentration of 2g / L at 82°C for 2.5 hours, then cool it to 24°C with running water and filter it with a Buchner funnel to collect the liquid, then Add hydrochloric acid until the final concentration of hydrochloric acid is...
Embodiment 2
[0035] Preparation of hydrophobic oat dextran with different degrees of substitution:
[0036] Take 100 mL of the oat glucan hydrolyzate obtained in Example 1, add octenyl succinic anhydride equivalent to 1 / 1000 to 1 / 100 of the volume of the oat glucan hydrolyzate, and then adjust the pH with 3% sodium hydroxide After reaching 9, react at 15-55°C for 1-5 hours, then stir at 25°C for 12 hours and then let it stand for 1 hour, and finally adjust the pH to 6.5±0.3 with 2% hydrochloric acid to terminate the reaction ; Then transfer the hydrophobic oat glucan to the dialysis bag for 24 hours of running water dialysis, and then 24 hours of distilled water dialysis, and finally add isopropanol equivalent to 2 times the volume of the dialysate to the dialysate, and place it at a temperature of Under the condition of 50°C until the hydrophobic oat glucan precipitates, the reaction solution is centrifuged at 4000 rpm for 20 minutes, and finally the precipitate is vacuum-dried at 45°C fo...
Embodiment 3
[0042] According to the situation investigated in Example 2, hydrophobic glucans with different degrees of substitution were prepared:
[0043] (1) Preparation of hydrophobic dextran with a degree of substitution of 0.011, the steps are the same as in Example 2, the difference is:
[0044] Add 0.1mL of octenyl succinic anhydride to 100mL oat dextran hydrolyzate, then adjust the pH to 8 with 3% sodium hydroxide, react at 45°C for 1 hour, and then Stir for 12 hours at 25°C and then let it stand for 1 hour. Finally, adjust the pH to 6.5 with 2% hydrochloric acid to terminate the reaction; hours, and then dialyzed with distilled water for 24 hours, and finally added isopropanol equivalent to 2 times the volume of the dialysate to the dialysate, and placed at a temperature of 60°C until the hydrophobic oat dextran precipitated, and then the reaction solution was in Centrifuge at 4000 rpm for 20 minutes, and finally vacuum-dry the precipitate at 45°C for 12 hours to obtain hydropho...
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