A traditional Chinese medicine composition for treating seborrheic alopecia and alopecia areata and preparation method thereof

A technology for seborrheic alopecia and composition, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., and can solve problems such as unsatisfactory effect of traditional Chinese medicine composition

Active Publication Date: 2015-09-09
杨凌步长制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Because of this, an invention patent has been applied for this Chinese medicine composition, its publication number is CN1343516A, and the publication date is April 10, 2002. However, in the actual clinical application process, we found that the effect of the traditional Chinese medicine composition made by the above preparation method is not ideal, and the patent application is to further optimize the preparation process through a large number of experiments, and find a more The best preparation process and parameters have been proved by clinical trials to be more effective. Therefore, we have successfully developed a traditional Chinese medicine combination for the treatment of seborrheic alopecia and alopecia areata for the purpose of improving the stability and bioavailability of the preparation. thing

Method used

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  • A traditional Chinese medicine composition for treating seborrheic alopecia and alopecia areata and preparation method thereof
  • A traditional Chinese medicine composition for treating seborrheic alopecia and alopecia areata and preparation method thereof
  • A traditional Chinese medicine composition for treating seborrheic alopecia and alopecia areata and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] (1) Ginseng 28g, yam 69g, Codonopsis 56g, Cortex Moutan 49g, Anemarrhena 62g, Poria cocos 56g were pulverized into coarse powder, and then superfinely pulverized into 75 μm medicinal powder;

[0063] (2) Take 208 g of Radix Polygoni Multiflori, crush it into coarse powder, infiltrate it with 60% ethanol, carry out percolation with 60% ethanol with a weight ratio of 7 times of the material, collect the percolation liquid, recover ethanol under reduced pressure, concentrate, dry, and pulverize into Dried ointment powder, sieved, dregs for standby;

[0064] (3) Take 83 g of Cornus officinalis, 104 g of Eclipta arborvitae, 139 g of Arborvitae leaves, and 42 g of Alisma alisma, add 70% ethanol with a weight ratio of 9 times of medicinal materials, reflux extraction twice, each time for 2 hours, filter, combine the filtrates and recover ethanol to After the alcohol smell is gone, the medicinal solution is concentrated and dried, and crushed into a dry cream powder, sieved, an...

Embodiment 2

[0068] ⑴ Grind 28g ginseng, 69g yam, 56g Codonopsis pilosula, 49g Moutan cortex, 62g Anemarrhena anemarrhena, and 56g Poria cocos into coarse powder, and then ultrafinely pulverize it into a 50μm medicinal powder;

[0069] (2) Take 208 g of Radix Polygoni Multiflori, crush it into coarse powder, infiltrate it with 50% ethanol, carry out percolation with 50% ethanol with a weight ratio of 7 times of the material, collect the percolation liquid, recover ethanol under reduced pressure, concentrate, dry, and pulverize into Dried ointment powder, sieved, dregs for standby;

[0070] (3) Take 83 g of Cornus officinalis, 104 g of Eclipta japonica, 139 g of Arborvitae leaves, and 42 g of Alisma alisma, add 60% ethanol with a weight ratio of 7 times of medicinal materials, reflux extraction once, 3 h each time, filter, combine the filtrate and recover ethanol After the alcohol smell is gone, the medicinal solution is concentrated and dried, and crushed into a dry cream powder, sieved, a...

Embodiment 3

[0074] ⑴ Grind 28g ginseng, 69g yam, 56g Codonopsis pilosula, 49g Moutan cortex, 62g Anemarrhena anemarrhena, and 56g poria cocos into coarse powder, and then ultrafinely pulverize it into a 25μm medicinal powder;

[0075] (2) Take 208 g of Radix Polygoni Multiflori, crush it into a coarse powder, infiltrate it with 70% ethanol, use 7 times the weight ratio of the material for percolation with 70% ethanol, collect the percolation liquid, recover ethanol under reduced pressure, concentrate, dry, and pulverize into Dried ointment powder, sieved, dregs for standby;

[0076] (3) Take 83 g of Cornus officinalis, 104 g of Eclipta arborvitae, 139 g of Arborvitae leaves, and 42 g of Alisma alisma, add 80% ethanol with a weight ratio of 10 times of medicinal materials, reflux extraction once, each time for 1 h, filter, combine the filtrate and recover ethanol After the alcohol smell is gone, the medicinal solution is concentrated and dried, and crushed into a dry cream powder, sieved, ...

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Abstract

The invention relates to a TCM composition for treatment of seborrheic alopecia and alopecia areata. The TCM composition comprises the following raw materials in parts by weight: 208 parts of prepared rehmannia root, 208 parts of radix polygonum multiflorum preparata, 208 parts of dried rehmannia root, 83 parts of dogwood, 104 parts of herba ecliptae, 69 parts of Chinese yam, 139 parts of cacumen biotae, 28 parts of ginseng, 56 parts of radix codonopsitis, 56 parts of Indian buead, 49 parts of tree peony bark, 42 parts of alisma, 62 parts of rhizoma anemarrhenae, 42 parts of cortex lycii radicis and 35 parts of radices stellariae dichotomae. The TCM composition is TCM oral liquid prepared by the steps of extracting and purifying the raw materials according to a certain technique and adding pharmaceutically acceptable auxiliary materials. According to the invention, the TCM oral liquid has the characteristics of simple and feasible preparation technology, safety, effectiveness, obvious pharmacological effect and remarkable clinical test effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating seborrheic alopecia and alopecia areata and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Seborrheic alopecia is called "white dandruff wind" in traditional Chinese medicine, and also known as male pattern baldness in western medicine, androgenetic alopecia, diffuse alopecia, which is a baldness that progresses slowly on the forehead, temporal, and top after puberty, and can be used by both sexes Occurs, but is more common in male patients. It is also a common and frequently-occurring disease in dermatology clinics, and it is also one of the refractory diseases. Modern medicine thinks that the occurrence of this disease is related to imbalance of sex hormones and excessive secretion of sebaceous glands. Clinically, patients with this disease are often accompanied by more seborrhea on the head,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61P17/14
Inventor 赵步长
Owner 杨凌步长制药有限公司
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