Water based ivermectin O/W injection and preparation method thereof

Abstract

The invention discloses a water based ivermectin O / W (oil-in-water) injection and a preparation method thereof. The O / W injection consists of medium-chain triglycerides, soybean lecithin, 1, 2-propylene glycol, polyoxyethylated 12-hydroxystearic acid, ivermectin and injection water. The key of the ivermectin O / W injection comprises the formula compositions of the injection and the content of each component. The injection has water as the matrix and contains a small amount of an organic solvent, so that the influences of the organic solvent on livestock and poultry and environment are reduced, and the injection has little harm to producers and users, and is safer to store and transport; and also the injection has little toxic and side effects on livestock and poultry, and helps to solve the problems of harm to livestock and poultry and pollution on environment caused by conventional dosage forms during production and use.

Description

technical field [0001] The invention belongs to the field of veterinary medicines, and relates to medicines for preventing and treating nematodes and arthropod insects in livestock and poultry, in particular to a water-based ivermectin O / W injection and a preparation method thereof. [0002] Background technique [0002] Ivermectin (Ivermectin, hereinafter referred to as IVM) is a semi-synthetic macrolide antibiotic. Nematodes and arthropod insects in vitro have a good repellent effect and are widely used in animal husbandry production. However, its wide clinical application is limited due to its extremely low water solubility, very poor storage stability and strong toxicity. Contents of the invention Aiming at the defects and deficiencies of the above-mentioned ivermectin low water solubility and poor storage stability, the object of the present invention is to provide a water-based ivermectin O / W type injection, which is used in veterinary clinics to resist nematodes...

AI Technical Summary

Problems solved by technology

Aiming at the defects and deficiencies of the above-mentioned ivermectin low water solubility and poor storage stability, the object of the present invention is to provide a water-based ivermectin O / W type injection, which is used in veterinary clinics to resist nematodes in animals. and arthropods in vitro, thereby enhancing the therapeutic effect of ivermectin

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