Chinese angelica blood-nourishing compound microcapsule capable of promoting angiogenesis and preparation method thereof

A technology of angiogenesis and angelica, applied in the field of angelica nourishing blood compound microcapsules and its preparation, can solve the problems of inconvenient carrying, low dissolution rate, difficulty in taking, etc., and achieve good precision and good molding effect

Active Publication Date: 2013-12-11
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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AI Technical Summary

Problems solved by technology

[0005] The traditional Danggui Buxue Decoction is a decoction, which has the disadvantages of low dissolution rate, difficulty in taking, and inconvenience in carrying. Polysaccharides, ferulic acid and other parts that have the effects of nourishing qi, nourishing energy and promoting angiogenesis are extracted and combined simply to make common dosage forms such as granules, which cannot completely replace the compound formula of Danggui Buxue Decoction, because Astragalus, Danggui A variety of active ingredients in Danggui Buxue Decoction have a synergistic effect when they are co-decocted. The content of astragaloside IV, astragalus polysaccharide and ferulic acid is much higher than that of single decoction. Therefore, there is no certain part, part or monomer in Danggui Buxue Decoction that can represent Quan Fang Efficacy and Its Material Basis
Therefore, based on the existing research, there is no idea of ​​applying Danggui Buxue Decoction with the holistic view of traditional Chinese medicine and combining modern Chinese medicine microcapsule technology to improve the drug performance while changing the dosage form of Danggui Buxue Decoction.

Method used

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  • Chinese angelica blood-nourishing compound microcapsule capable of promoting angiogenesis and preparation method thereof
  • Chinese angelica blood-nourishing compound microcapsule capable of promoting angiogenesis and preparation method thereof
  • Chinese angelica blood-nourishing compound microcapsule capable of promoting angiogenesis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The selection of embodiment 1 angelica tonifying blood compound prescription microcapsule preparation method

[0029] method one):

[0030] Weigh 2kg of astragalus according to the mass ratio, soak 400g of angelica medicinal materials for 2 hours, decoct in water for 2 hours, decoct twice, concentrate the medicinal liquid decocted twice to a concentrated solution of 2.4kg, and precipitate with 80% alcohol , put it under the refrigerator for 12 hours, take it out, pour out the supernatant, and distill ethanol in a rotary evaporator to obtain about 500ml of Chinese angelica blood-enriching compound extract, place it in a vacuum desiccator and dry it at low temperature until there is no moisture in the extract, and weigh it.

[0031] Use a 50ml syringe to draw the sodium alginate solution of the extract of Danggui Buxue Decoction into the needle tube, configure a No. 9 needle, and slowly add it dropwise into the calcium chloride solution stirred by a magnetic stirrer. Yel...

Embodiment 2

[0037] Example 2 Process Research on the Preparation of Angelica Buxue Compound Microcapsules

[0038] Using the microcapsules of Danggui Buxue Decoction obtained in Example 1, the influencing factors of the ratio of microcapsule materials were investigated, and sodium alginate 1.5%, chitosan 0.3%, and Danggui Buxue Decoction were screened out from the aspects of single factor, orthogonal test and verification test respectively. Drug concentration 0.4g / mL, calcium chloride concentration 2%. The embedding rate can reach 59.92%, which shows a good molding effect and can meet the purpose and requirements of microcapsule preparation. (See Table 1 for orthogonal experiments, Table 2 for ANOVA, and Table 3 for verification tests)

[0039] Table 1 Orthogonal test results

[0040]

[0041] Table 2 Analysis of variance

[0042]

[0043] Table 3 verification test results

[0044]

Embodiment 3

[0045] Example 3 Quality Evaluation of Danggui Buxue Decoction Microcapsules

[0046] According to the optimal process result of Danggui Buxue Decoction microcapsules in Example 2, select 3 groups of optimal process gained microcapsules, and carry out quality evaluation from the following aspects respectively:

[0047] (1) Microcapsule morphology and particle size distribution

[0048] The shape of Danggui Buxue Decoction microcapsules prepared under the optimal process parameters was observed by biological microscope and imaging system, and 200 microcapsules were randomly selected for particle size determination. figure 1 It can be seen that the shape of the microcapsules is spherical, and the distribution is generally uniform; figure 2 It is the morphology of the microcapsule after 60 times magnification; image 3 It can be seen that the particle size distribution of 200 microcapsules is mainly concentrated between 800-900um.

[0049] (2) Effects of extracts on liver fun...

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Abstract

The invention provides a compound extract prepared from an existing prescription Chinese angelica blood-nourishing decoction to overcome the defect of the Chinese angelica blood-nourishing preparation in the prior art. The compound extract is integrally embedded to realize microencapsulation, the effect of the compound extract can be maintained, and the advantage of microencapsulation can be played. According to a preparation method of the compound extract, the Chinese angelica blood-nourishing decoction is extracted by a water extraction and alcohol precipitation method; a complex coacervation method is used as a method for preparing the Chinese angelica blood-nourishing decoction microcapsules, and sodium alginate, chitosan, calcium chloride and concentrations thereof are screened to serve as a proper capsule material. The Chinese angelica blood-nourishing compound microcapsules can overcome the defects that a traditional decoction is low in dissolution, difficult to take, not convenient to take and the like, the integral drug effect of the Chinese angelica blood-nourishing decoction is not influenced because the compound is integrally embedded, a sustained-release effect can be achieved due to the microencapsulated preparation, and the integral performance of the traditional Chinese angelica blood-nourishing decoction can be greatly improved. The preparation method is simple in extraction process, safe in reagent and simple and practical in microcapsule preparation process, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to an angiogenesis-promoting compound microcapsule of angelica and blood and a preparation method thereof. Background technique [0002] Angiogenesis plays an important role in tissue regeneration, wound repair, and ischemic diseases. Traditional Chinese medicine has its own characteristics and advantages in treating trauma and ischemic diseases. Chinese herbal medicines or compound prescriptions are safe, effective, and cheap. Currently, the research on angiogenesis of traditional Chinese medicines is in the ascendant. It is of great social and economic significance to explore Chinese medicines or compound prescriptions that promote angiogenesis and to study their mechanisms. [0003] Danggui Buxue Decoction is a classic prescription for invigorating qi and promoting blood. It is composed of astragalus and angelica in a ratio of 5:1. Modern stud...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K9/50A61P17/02A61P9/10
Inventor 潘立群景海波潘自皓
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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