Paper-based microfluid device capable of automatically switching passages and application of paper-based microfluid device

Abstract

The invention discloses a paper-based microfluid device capable of automatically switching passages and an application of the paper-based microfluid device. The paper-based microfluid device comprises a plurality of paper-based microfluid single layers which are superimposed and respectively comprise a hydrophobic isolation area and a hydrophilic microflow passage, the paper-based microfluid single layers form microflow passages, and each microflow passage is provided with a microflow switch; water absorption resin is arranged between each microflow passage and the corresponding microflow switch, after liquid flows into the water absorption resin, the resin is expanded after absorbing water to downward push each microflow switch and a reagent carrying gasket below the microflow switch, and after the reagent carrying gasket moves downwards to be contacted with the microflow passage below the reagent carrying gasket, and another microflow passage is opened, so that the automatic switching of the passages can be completed. By adopting the paper-based microfluid device, the function of a paper-based microfluid for automatically switching the passage can be realized, multiple biochemical reagents can be introduced through the automatic switching of the passages under the situation that no auxiliary device and profession personnel are needed, the multi-step biochemical reaction can be carried out, and the device is used as one part of a biochemical detection device, so that the biochemical detection device is miniaturized, and the paper-based microfluid device has a function for amplifying a detected information molecule.

Description

technical field [0001] The invention relates to a paper-based microfluidic device, in particular to a paper-based microfluidic device for automatically switching channels and an application thereof. Background technique [0002] Microfluidic chips have become a research hotspot in the field of biochemical analysis due to their small size, low sample consumption, relatively simple operation and powerful analysis functions. It can be applied in many fields such as security. Compared with microfluidic chips, paper-based microfluidic chips, as a "simplified version" of microfluidic devices, have significant advantages such as low cost, portability, simple operation, and no need for any additional devices and professionals. widely valued. [0003] The paper-based microfluidic device is to treat the paper (such as spraying wax or other hydrophobic substances on the paper) to form a hydrophilic microfluidic channel and a hydrophobic isolation area. The hydrophobic isolation area ...

AI Technical Summary

Problems solved by technology

Therefore, when the existing paper-based microfluidic device is used for biochemical detection, because it cannot complete multi-step biochemical reactions, its detection sensitivity is limited, and its application is subject to certain restrictions.

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