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Fermented composition for preventing and treating digestive system diseases

A technology for digestive system diseases and extracts, which is applied in the field of the influence of probiotics on the biological activity of traditional Chinese medicine extracts, and can solve problems such as the inability to detect quercetin metabolites

Active Publication Date: 2013-12-18
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, early studies by Dooth et al. (Dooth AN et al.., J. Biol. Chem., 223:251, 1956) found that after oral administration of quercetin to mice, 3, B-ring cleavage products such as 4-dihydroxyphenylacetic acid, but these quercetin metabolites cannot be detected in urine if the animals are pre-administered with antibiotics (such as neomycin)

Method used

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  • Fermented composition for preventing and treating digestive system diseases
  • Fermented composition for preventing and treating digestive system diseases
  • Fermented composition for preventing and treating digestive system diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Preparation of fermented composition of traditional Chinese medicine compound for invigorating the spleen and stomach by probiotic fermentation

[0022] Weigh each Chinese medicine ingredient according to the following weights: 75g of malt, 50g of hawthorn, 50g of poria cocos, 25g of tangerine peel, 25g of jujube, 10g of licorice, 9g of ginger, and 41g of fresh radish. Extract juice from ginger and fresh radish, add 8 times the amount of water to soak the other six traditional Chinese medicines for 30 minutes, extract at 100°C for 1 hour, filter, add 6 times the amount of water to the filter residue, extract at 100°C for 1 hour, filter, and combine the filtrates , concentrated under reduced pressure to 2:1-4:1 (that is, every 2-4ml extract is equivalent to 1g medicinal material). Add ginger and fresh radish juice, and set the volume to 1000ml to obtain the compound Chinese medicine extract. Then add an appropriate amount of glucose (1.0%), peptone (0.4%), ye...

Embodiment 2

[0025] Example 2: small intestine propulsion experiment of fermented composition of the present invention and unfermented Chinese medicine compound extract

[0026] The purpose of this example is to demonstrate that the fermented composition prepared by the method of the present invention is better than the non-fermented Chinese medicine compound extract by using the small intestine propulsion experiment of mice.

[0027] The fermented composition prepared in Example 1 and the compound extract of traditional Chinese medicine without probiotic fermentation prepared in a similar manner were concentrated to the same concentration respectively as test samples.

[0028] Forty male mice weighing 18-22 g were randomly divided into 4 groups, 10 in each group, which were model control group, unfermented Chinese medicine compound extract group, fermented composition group, and blank control group. The test samples were given orally, and the control group was given water in the same way,...

Embodiment 3

[0035] Example 3: Effects of the fermented composition of the present invention and unfermented traditional Chinese medicine compound extract on rat body weight, food intake and digestive enzymes

[0036] The purpose of this example is to use the effects on rat body weight, food intake and digestive enzymes to illustrate that the fermented composition prepared by the method of the present invention is superior to the non-fermented traditional Chinese medicine compound extract.

[0037] The fermented composition prepared in Example 1 and the compound extract of traditional Chinese medicine without probiotic fermentation prepared in a similar manner were concentrated to the same concentration respectively as test samples.

[0038] Select 30 clean-grade male rats, weighing 140-150 g, and randomly divide them into 3 groups, 10 rats in each group, blank control group, non-fermented traditional Chinese medicine compound extract group, and fermented composition group. The test sample...

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Abstract

The invention relates to the influence produced by probiotics on biological activity of traditional Chinese medicine extract and especially relates to a method for intestinal probiotic fermentation on spleen and stomach strengthening traditional Chinese medicine compound extract for purpose of improving digestive system disease prevention and treatment. The invention further relates to a fermented composition for preventing and treating digestive system diseases. The fermented composition is obtained by intestinal probiotic fermentation on malt, haw, poria cocos, dried orange peel, jujube, licorice, ginger and radish extract. The invention also relates to a use of the fermented composition in preparation of foods, health foods or medicines for preventing and treating digestive system diseases.

Description

technical field [0001] The invention relates to the influence of probiotics on the biological activity of traditional Chinese medicine extracts, in particular to the method for improving and improving the prevention and treatment of digestive system diseases by fermenting spleen and stomach traditional Chinese medicine extracts with probiotics in the intestines. The present invention further relates to a fermented composition prepared by fermenting extracts of malt, hawthorn, Poria cocos, tangerine peel, jujube, licorice, ginger, and radish through intestinal probiotics, and the fermented composition is used for preventing and treating digestive system Disease food, health food or medicine application. technical background [0002] The material basis of Chinese herbal medicine for treating diseases is the chemical substances contained in it. After these chemical substances enter the human body orally in the form of traditional decoction, that is, water extract, they can show...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/00A23L1/29A23L33/00
Inventor 褚新红牛纪江孙筱林冯淑琴吴炳新
Owner SANZHU FUER PHARMA
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