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Fructus aurantii immaturus or fructus aurantii extract, its preparation method and application

A technology of extract and citrus aurantium, applied in the field of citrus aurantium or citrus aurantium extract and its preparation, can solve the problems of large dose, long onset time, unsatisfactory use effect, etc., achieve small dosage and simple production method , easy to carry effect

Inactive Publication Date: 2013-12-25
GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the past research and utilization, most of them were based on the ancient compound preparations. There was not enough research on the monarch drug Fructus Aurantii or Fructus Fructus Fructus Fructus Fructus Fructus Aurantii, and the effect of using it was often not ideal; to have a curative effect on diseases, a larger dose was needed , and the onset time is longer
In terms of the methods of its development and utilization, they are all compound preparations, which are used in combination with other traditional Chinese medicines, and no single prescription has been seen, especially in the aspect of relieving cough and reducing phlegm.

Method used

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  • Fructus aurantii immaturus or fructus aurantii extract, its preparation method and application
  • Fructus aurantii immaturus or fructus aurantii extract, its preparation method and application
  • Fructus aurantii immaturus or fructus aurantii extract, its preparation method and application

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Effect test

Embodiment 1

[0037] This embodiment is a pharmaceutical composition with the effect of relieving cough and resolving phlegm, which is composed of the water extract of Fructus Fructus Citrus Fructus as active ingredient and pharmaceutically acceptable excipients.

[0038] The preparation method is as follows:

[0039] (1) Preparation of Aurantium citrus water extract:

[0040] Crush the whole fruit of Citrus aurantium, pass through a 20-mesh sieve, add 100°C water to submerge the medicinal materials (the amount of water used is 5 times the volume of the raw medicine of Citrus aurantium), extract twice, 1 hour each time, filter, collect volatile oil at the same time, combine the filtrate, Concentrate into an extract and combine with the volatile oil to obtain the water extract of Fructus Aurantii, with an extraction rate of about 30%.

[0041] (2) The water extract of Aurantium citrus Fructus obtained in step (1) and conventional auxiliary materials are prepared into an oral liquid.

Embodiment 2

[0043] This embodiment is a pharmaceutical composition with the effect of relieving cough and resolving phlegm, which is composed of the water extract of Fructus Fructus Fructus Fructus as active ingredient and pharmaceutically acceptable excipients.

[0044] The preparation method is as follows:

[0045] (1) Preparation of Aurantii Fructus Water Extract:

[0046] The whole fruit of Fructus Fructus is crushed, passed through a 20-mesh sieve, covered with 100°C water (the amount of water used is 8 times the volume of the raw material of Fructus Fructus Fructus), extracted 3 times, 1 hour each time, filtered, and the volatile oil was collected at the same time, and the filtrate was combined. Then it is concentrated into an extract and combined with volatile oil to obtain the water extract of Fructus Fructus Aurantii, with an extraction rate of about 30%.

[0047] (2) The water extract of Fructus Aurantii obtained in step (1) and conventional auxiliary materials are made into ta...

Embodiment 3

[0049] In this embodiment, a pharmaceutical composition with the effect of relieving cough and reducing phlegm is composed of the water extract of Fructus Fructus Fructus Fructus and Fructus Fructus Fructus as active ingredients and pharmaceutically acceptable excipients, wherein the dosage of Fructus Fructus Fructus Fructus Fructus Fructus Fructus Fructus Water Extract and Fructus Fructus Fructus Fructus Water Extract are used The ratio is 1:1.

[0050] The preparation method is as follows:

[0051] (1) Preparation of Aurantium Fructus or Aurantium Fructus Water Extract:

[0052] The whole fruit of Fructus Aurantii or Fructus Fructus is crushed, passed through a 20-mesh sieve, covered with 100°C water (the amount of water used is 5 times the volume of the raw material drug of Fructus Fructus Fructus Fructus Fructus Fructus Fructus Fructus Fructus or Fructus Fructus Fructus), extract 3 times, each time for 1 hour, filter, and at the same time Collect the volatile oil, combine...

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Abstract

The invention discloses a fructus aurantii immaturus or fructus aurantii extract, its preparation method and application. The fructus aurantii immaturus or fructus aurantii extract is prepared by: crushing a whole fructus aurantii immaturus or fructus aurantii fruit, conducting water extraction or alcohol extraction 1-3 times, at the same time collecting volatile oil, performing filtration and combining the filtrate, adding or not adding an organic solvent to conduct extraction, then carrying out concentration to obtain extractum, and combining the extractum with volatile oil, thus obtaining the fructus aurantii immaturus or fructus aurantii extract. The extract can be applied in preparation of pharmaceutical compositions for relieving cough and reducing sputum, and can achieve good cough relieving and sputum reducing effects. The production method is simple, and the effective component extraction rate is high.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an extract of Fructus Fructus Fructus Fructus Fructus or Fructus Fructus Fructus Fructus Fructus Aurantii and its preparation method and application. Background technique [0002] Fructus aurantii immaturus is the young fruit of Citrus aurantium L., Poncirus trifoliata (L.) Raf. or Citrus wilsonii Tanaka, which are mainly used for stagnant internal stagnation, Fullness, pain, diarrhea, etc. [0003] Fructus aurantii (Fructus aurantii) is the dry immature fruit of Citrus aurantium L. and its cultivars of the Rutaceae plant. [0004] Citrus aurantium and Fructus aurantium are commonly used traditional Chinese medicines, which have been used clinically for more than 2,000 years and are widely used in compound preparations for treating diseases in traditional Chinese medicine. Pharmacological experiments have shown that citrus aurantium medicine can increase t...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P11/14A61P11/10
Inventor 白杨刘小蓉
Owner GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
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