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pH nanometer sensing material with upconversion luminescence property, and preparation method thereof

A sensing material, rare earth up-conversion technology, applied in luminescent materials, nanotechnology for materials and surface science, nanotechnology, etc., to achieve high upconversion efficiency, uniform particle size, and small particle size

Inactive Publication Date: 2013-12-25
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
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Problems solved by technology

[0007]However, although the research on rare earth up-conversion luminescent nanomaterials has achieved a lot of results, their application in life science research is seldom, the main reason is that it is difficult to Preparation of nanomaterials with small particle size, high upconversion luminescence efficiency, good water solubility and biocompatibility

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  • pH nanometer sensing material with upconversion luminescence property, and preparation method thereof
  • pH nanometer sensing material with upconversion luminescence property, and preparation method thereof
  • pH nanometer sensing material with upconversion luminescence property, and preparation method thereof

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Embodiment Construction

[0034] This embodiment provides an organic-inorganic hybrid rare-earth up-conversion luminescent nanomaterial, which includes a rare-earth up-conversion luminescent nanocrystal and a xylenol orange layer coated on the rare-earth up-conversion luminescent nanocrystal. The particle size of the rare earth up-conversion luminescent nanocrystal is 50-70 nm. The rare-earth up-conversion luminescent nanocrystals are composed of any two or more combinations of ytterbium, yttrium, thulium, and erbium. Concrete preparation route is shown in the following formula:

[0035]

[0036] S1. Add 795 μL of yttrium trichloride (0.1 mol / L), 1000 μL of ytterbium trichloride (0.2 mol / L), and 50 μL of thulium trichloride (0.1 mol / L) into a 100 mL three-necked flask, and add 6 mL oleic acid and 15 mL octadecene, 150 o C, heated and stirred until the solution was clear, added 10 mL of methanol solution containing 100 mg of sodium hydroxide and 148 mg of ammonium fluoride, at 50 o C under heating...

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Abstract

The present invention relates to a pH nanometer sensing material with upconversion luminescence property, and a preparation method thereof. According to the present invention, a fluoride is adopted as a matrix, and is doped with trivalent rare earth ions to obtain a rare earth upconversion luminescence nanometer crystal, in order to broaden applications of the rare earth upconversion luminescence nanometer crystal in the organism environment, surface modification is performed on the nanometer crystal from hydrophilicity / hydrophobicity of a surface ligand, ligand electric charge, coordination capacity and other angles, silica coating is performed on the surface of the nanometer crystal to functionalize the amino group, and the obtained material and an organic dye xylenol orange are conjugated to obtain a composite nanometer crystal, wherein the size is 44-80 nm, and the composite nanometer crystal can be well dispersed in water and can be stable in aqueous solutions. In addition, the composite nanometer crystal has characteristics of controllable size, uniform particle size and good biocompatibility, and can be used for detection of solution pH values and pH values in living cells.

Description

Technical field: [0001] The invention belongs to the technical field of luminescent nanometer materials. It specifically relates to the preparation of a kind of inorganic rare earth up-conversion luminescent nanoparticles coupled with organic fluorescent dyes and its application in biological detection and biological imaging. Background technique: [0002] The conduct or completion of chemical reactions, many important physiological processes of cells and organelles, etc. are closely related to the pH value. Under normal physiological conditions, the extracellular fluid needs a constant concentration of hydrogen ions. Too strong acidity and alkalinity will lead to Heart, lung or neurological diseases can even be life-threatening in severe cases. Therefore, accurate measurement of pH value is very important for chemical biology research. [0003] It is well known that the fluorescence or absorption properties of some organic compounds will change with pH, ​​and pH fluores...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/77C09K11/02G01N21/64G01N21/31B82Y30/00B82Y20/00B82Y40/00
Inventor 赵强黄维张利利许文娟刘淑娟张幸林赵新
Owner NANJING UNIV OF POSTS & TELECOMM
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