New application of traditional Chinese medicine compound medicinal composition

A technology of medicines and uses, applied in the field of traditional Chinese medicine compound pharmaceutical compositions, can solve the problems of PMSG application reports that have not been seen, reduce fertilization and cleavage ability, etc., and achieve the goal of promoting oocyte nuclear maturation, improving the success rate of IVF, and expanding the application space Effect

Active Publication Date: 2014-01-01
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A certain concentration of 17β-E 2 It has the effect of promoting cytoplasmic maturation of egg cells, which is beneficial to fertilization and further development of embryos, but if the concentration is too high, it will reduce the ability of fertilization and cleavage
There is no report on the application of PMSG in in vitro maturation of mouse oocytes
(4) At present, there are no other recognized drugs for promoting oocyte maturation in vitro
However, using Zuogui Pills for assisted reproduction, such as the in vitro maturation (IVM) technology of oocytes, there is no relevant literature report at present.

Method used

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  • New application of traditional Chinese medicine compound medicinal composition
  • New application of traditional Chinese medicine compound medicinal composition
  • New application of traditional Chinese medicine compound medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of Pharmaceutical Composition 1 of the present invention (Zuogui Pills)

[0032] Weigh raw materials: Rehmannia glutinosa 200g, dodder 100g, achyranthes bidentata 75g, tortoise shell glue 100g, deer horn glue 100g, yam 100g, dogwood 100g, medlar 100g;

[0033] Preparation method: The above eight flavors, except for antler glue and tortoise shell glue, the other six flavors such as rehmannia glutinosa are crushed into fine powder, sieved and mixed. Take deer horn glue and tortoise shell glue to melt, and mix with the above fine powder. For every 100g of powder, add 10g of refined honey and an appropriate amount of water, make pills, and dry to get the product; or without adding honey, just powder.

Embodiment 2

[0034] Example 2 Preparation of pharmaceutical composition 2 of the present invention (Yougui Pills)

[0035] Weigh raw materials: Rehmannia glutinosa 24g, yam 12g, dogwood 9g, medlar 9g, dodder 12g, antler gum 12g, Eucommia 12g, cinnamon 6g, angelica 9g, aconite 6g.

[0036] Preparation method: Steam the rehmannia glutinosa into a pestle paste, and make the rest into fine powder, dry and seal it for storage, mix it with water to take, or add refined honey to make pills, which are as big as marbles. Take two or three pills (6-9g) each time you chew, and serve with boiled soup.

Embodiment 3

[0037] Embodiment 3 preparation of medicine of the present invention

[0038] Weigh raw materials: Rehmannia glutinosa 24g, dogwood 12g, yam 12g, medlar 12g, dodder 12g, antler glue 12g;

[0039] Preparation method: The above six flavors, except the antler gum, the other six flavors such as Rehmannia glutinosa are crushed into fine powder, sieved and mixed. Take the deer horn gelatin, mix it with the above fine powder, dry and seal it for storage, and take it with water, or add 10g of refined honey and an appropriate amount of water for every 100g of powder.

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Abstract

The invention provides a purpose for preparing supplementary reproduction medicine from the following raw material medicine in percentage by weight: 18 to 30 parts of radix rehmanniae preparata, 9 to 12 parts of dogwood, 8 to 16 parts of Chinese yam, 9 to 12 parts of fructus lycii, 8 to 16 parts of semen cuscutae and 8 to 16 parts of antler gum. The invention also provides a method for promoting ovarian ovum in vitro maturation. The method comprises the following steps that a, an immature ovarian ovum is taken; and b, the immature ovarian ovum is placed in M199 culture liquid, a microdrop method is adopted for culture for 24 hours, and a mature ovarian ovum is obtained, wherein 2 percent of medicine is contained in the culture liquid. The medicine can promote the growth and development of the immature ovarian ovum in vitro and mainly promotes the ovarian ovum core maturation, and in addition, the cytoskeleton abnormality probability of the mature ovarian ovum is not increased. The medicine can also generate the influence on the ovum passing capability of sperms, and the reliable basis is provided for clinically preventing and treating the male sperm dysfunction, improving the IVF (in vitro fertilization) success ratio and reducing the use rate of ICSI (intracytoplasmic sperm injection).

Description

[0001] This application is a divisional application of patent application number: 201210292197.1. The original application number is: 201210292197.1, the application date is: August 16, 2012, the name of the invention: new application of traditional Chinese medicine compound pharmaceutical composition. technical field [0002] The present invention relates to a new application of a traditional Chinese medicine compound pharmaceutical composition, in particular, the application in the preparation of medicaments for assisted reproduction. Background technique [0003] In recent years, due to serious environmental pollution, increased work pressure, changes in eating habits, reproductive system diseases and other factors that adversely affect normal conception, the number of infertile patients is on the rise, with an incidence rate of about 12.5% ​​to 15%. increasing trend year by year. Therefore, the World Health Organization (WHO) announced that infertility, cardiovascular d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/21A61P15/08C12N5/075A61K35/56A61K35/32A61K35/586
Inventor 陆华高小平刘志斌
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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