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Detection method and device for high-sensitivity and high-reproducibility surface enhanced Raman spectroscopy

A surface-enhanced Raman and detection method technology, which is applied in the field of molecular spectrum analysis and detection, can solve problems such as poor reproducibility, influence on substrate application, and low repeatability of detection results, and achieve low cost, high reproducibility, analytical sensitivity, detection short cycle effect

Active Publication Date: 2014-01-01
胡建明
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Problems solved by technology

However, due to the roughness of the base layer of the substrate, irregular mutations in a certain range will appear after SERS irradiation and reflection, so the detection has a certain degree of discreteness and poor reproducibility, resulting in repeated accuracy of detection results. Not high, affecting the application of the substrate

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  • Detection method and device for high-sensitivity and high-reproducibility surface enhanced Raman spectroscopy

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Embodiment Construction

[0030] The highly sensitive and highly reproducible surface-enhanced Raman spectroscopy detection method of this embodiment includes the following steps:

[0031] a. Coat the sample to be tested uniformly on the SERS substrate; the coating method can be dot-like multi-dot distribution or planar distribution;

[0032] b. Use a light source to illuminate one of the samples to be tested on the SERS substrate through an illumination system and obtain its Raman spectrum; use surface-enhanced Raman spectroscopy to obtain the content of the sample, which belongs to the prior art and will not be repeated here;

[0033] c. Perform multi-point detection on samples within the range of samples on the SERS substrate and repeat step b;

[0034] d. Using the obtained spectrum information of the sample to be tested at multiple points, get the average value after removing the background. According to the average value, the minimum and maximum values ​​of the measured spectrum information of the sample ...

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Abstract

The invention discloses a detection method and device for high-sensitivity and high-reproducibility surface enhanced Raman spectroscopy. The method that detection is performed repeatedly to obtain the average value is adopted, the problem of relatively high discreteness in the existing detection method is avoided, the method and the device have high reproducibility and ultrahigh analytical sensitivity, and are suitable for detection of ultratrace samples, detection results can be obtained accurately, the operation is simple, and the detection period is short. According to the method, a fine-tuning device is adopted, so that the movement of a substrate is achieved so as to perform multi-point detection, the device is simple in structure, lower in cost, and easy and convenient to operate; the method and the device provide conditions for further promoting the SERS technology to be widely used in the fields of homeland security, environmental monitoring, food safety, health care and the like.

Description

Technical field [0001] The invention relates to the field of molecular spectrum analysis and detection, in particular to a method and device for detecting surface enhanced Raman spectroscopy with high sensitivity and high reproducibility. Background technique [0002] In order to solve the problem of low sensitivity of Raman effect in the detection and analysis field in the prior art, surface enhanced Raman spectroscopy analysis technology has emerged. Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity spectroscopy technique developed in the 1990s with the development of nanotechnology. Like Raman spectroscopy, SERS can be used to accurately and qualitatively identify samples. SERS has ultra-high analytical sensitivity, which is about 6-10 orders of magnitude higher than ordinary Raman analysis. It can analyze research objects as small as single molecules and as large as cellular level. [0003] In practical applications, the direct drop of sample solution on the SE...

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Application Information

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IPC IPC(8): G01N21/65
Inventor 胡建明
Owner 胡建明
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