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Preparation method and application of liver protection tablet

A technology of Hugan Tablets and Yinchen, which is applied in the field of preparation of Hugan Tablets, can solve the problems of large dosage for patients, rough process, and backwardness, and achieve the effect of reducing the dosage

Active Publication Date: 2014-01-08
上海宝龙安庆药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Hugan Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients, which is inconvenient to take, and seriously Affected the clinical application of this product

Method used

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  • Preparation method and application of liver protection tablet

Examples

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Effect test

Embodiment 1

[0016] Take Bupleurum 250g, Yinchen 250g, Radix Isatidis 250g, Schisandra chinensis 300g, pig gallbladder powder 20g, and mung bean 128g and add it to the CO2 supercritical extractor. Ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%. Pressure 15MPa, temperature 30℃, CO 2 The flow rate is 1m1 / g crude drug·min, and the extraction time is 150min to obtain a supercritical extract, add starch, granulate with 70% ethanol, dry, and press into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take Bupleurum 250g, Yinchen 250g, Banlangen 250g, Schisandra 300g, pig gallbladder powder 20g, mung bean 128g and add to CO 2 In the supercritical extractor, ethanol is used as the entrainer, the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50℃, CO 2 The flow rate was 3m1 / g crude drug·min, and the extraction time was 180min, to obtain a supercritical extract, add starch, granulate with 70% ethanol, dry, and press into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take Bupleurum 250g, Yinchen 250g, Banlangen 250g, Schisandra 300g, pig gallbladder powder 20g, mung bean 128g and add to CO 2 In the supercritical extractor, ethanol was used as the entrainer, the volume percentage of the entrainer in the total extraction solvent was 5%, the extraction pressure was 20MPa, the temperature was 40°C, and the CO 2 The flow rate was 2m1 / g crude drug·min, and the extraction time was 160min, to obtain a supercritical extract, add starch, granulate with 70% ethanol, dry, and press into tablets to make 500 tablets, each weighing 0.5g.

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PUM

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Abstract

The invention provides a preparation method of a liver protection tablet. The liver protection tablet is prepared by carrying out supercritical fluid extraction on the following raw herbal materials: 250g of bupleurum falcatum, 250g of capillary artemisia, 250g of isatis root, 300g of schisandra chinensis, 20g of pulvis fellis suis and 128g of mung bean, so that the content is greatly increased, and the dose is reduced. The invention also provides an application of the liver protection tablet in the preparation of a medicine for inhibiting the proliferation of a mouse lymphoma cell YAC-1.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a liver-protecting tablet. Background technique [0002] Liver protection tablets are recorded in the Pharmacopoeia, the prescription is Bupleurum 250g, Yinchen 250g, Banlangen 250g, Schisandra 300g, pig gallbladder powder 20g, mung bean 128g, the above six flavors, mung bean are crushed into fine powder; Bupleurum, Yinchen, Banlangen are boiled with water Two times, 2 hours each time, filter, combine the filtrates, let stand for 48 hours, take the supernatant, concentrate under reduced pressure into a clear paste with a relative density of 1.30 (80 ° C), mix with 101 g of mung bean powder, and dry under reduced pressure. Pulverize into fine powder; pulverize Schisandra chinensis into coarse powder, extract three times with 75% ethanol reflux, the first 3 hours, the second 2 hours, the third 1 hour, combine...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/57A61K9/20A61P1/16A61P35/00A61K35/413
Inventor 不公告发明人
Owner 上海宝龙安庆药业有限公司
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