Clean-in-place unit of pharmaceutical equipment

A pharmaceutical equipment and unit technology, which is applied in the field of on-site cleaning units for pharmaceutical equipment, can solve the problems of small cleaning units, affect the quality of medicines, and high work efficiency, and achieve the effects of small footprint, strong corrosion resistance, and improved work efficiency

Inactive Publication Date: 2014-01-15

JINAN SECESPOL HEAT EXCHANGE SYST

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AI-Extracted Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide an on-site cleaning unit for pharmaceutical equipment, which has small volume and high working effic...

Method used

Described heat exchanger 4 adopts 316L stainless steel to make, and corrosion resistance is strong, adopts uniform material, has uniform coefficient of thermal expansion, can not produce local stress when temperature changes, is difficult to leak, and two-way medium can not occur Cross-contamination provides a guarantee for the production q...

Abstract

The invention discloses a clean-in-place unit of pharmaceutical equipment. The clean-in-place unit of the pharmaceutical equipment comprises a tank body, a heat exchanger and a unit control cabinet, wherein the heat exchanger is a sterile double-tube-plate heat exchanger, the upper end of the tank body and the lower end of the tank body are both connected with the heat exchanger through pipelines, pneumatic diaphragm valves are arranged on the pipelines between the tank body and the heat exchanger respectively, a washing pump and a reflux pump are arranged on the pipeline between the lower end of the tank body and the heat exchanger, an electric control valve is arranged on a steam pipeline which is connected with the heat exchanger, two acid-base tanks are arranged below the tank body, the two acid-base tanks are connected to the tank body through metering pumps, and all valves are connected with the unit control cabinet. The clean-in-place unit of the pharmaceutical equipment has the advantages that working efficiency is high, the sterile double-tube-plate heat exchanger is not prone to leakage, cross contamination of bidirectional media is avoided, and production quality of drugs is guaranteed.

Application Domain

Cleaning using liquids

Technology Topic

RefluxDiaphragm valve +8

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Examples

Experimental program(1)

Example Embodiment

[0019] The present invention will be further described below in conjunction with the drawings and specific embodiments of the specification:

[0020] Such as figure 1 , figure 2 As shown, an in-place cleaning unit for pharmaceutical equipment includes a tank body 3, a heat exchanger 4 and a unit control cabinet 8. The heat exchanger 4 is a sterile double tube plate heat exchanger. The upper and lower ends are respectively connected to the heat exchanger 4 through pipelines. The pipeline between the tank 3 and the heat exchanger 4 is provided with a pneumatic diaphragm valve 5, and the pipeline between the lower end of the tank 3 and the heat exchanger 4 is provided There are a cleaning pump and a reflux pump. The steam pipe connected to the heat exchanger 4 is equipped with an electric regulating valve; there are two acid and alkali tanks 1 under the tank body 3, and the two acid and alkali tanks 1 are connected to the metering pump 2 respectively. Tank 3; each valve is connected to the unit control cabinet 8.

[0021] The tank body 3 is a special cleaning tank for pharmacy. The inner surface of the tank body 3 has a smoothness of less than 0.41 micron, and the outer surface of the tank body 3 is provided with a thermal insulation layer.

[0022] The thickness of the thermal insulation layer is 50 mm.

[0023] The tank body 3 is made of stainless steel, the corners inside the tank body 3 are all rounded, and the joints of the tank body 3 are all welded.

[0024] The pneumatic diaphragm valve 5 includes an upper valve and a lower valve, and the upper valve and the lower valve are arranged at the upper end of a distributor 6.

[0025] The pipelines are all designed without blind pipes and are completely drained. The pipeline meets the 3D design requirements.

[0026] The unit control cabinet 8 is provided with a man-machine interface 7, and the display screen of the man-machine interface 7 is a touch screen.

[0027] The heat exchanger 4 is made of 316L stainless steel, which has strong corrosion resistance, adopts a uniform material, and has a uniform coefficient of thermal expansion. It will not produce local stress when the temperature changes, is not prone to leakage, and will not cross-contaminate the bidirectional medium. Provided a guarantee for the production quality of drugs.

[0028] In the pharmaceutical equipment in-place cleaning unit of the present invention, the equipment in contact with the material is made of 316L stainless steel, and the unit can realize the online cleaning function and the self-disinfection function of the SIP in-situ disinfection system.

[0029] The pneumatic diaphragm valve 5 executes system transportation, circulation, pressure control, and diversion. The opening of each valve is automatically controlled by the unit control cabinet 8. The pipelines and valves can be independently cleaned with the help of the in-situ cleaning system to maximize Reduced cleaning dead spots.

[0030] The two acid and alkali tanks 1 respectively contain acid solution and lye solution, and are connected to the tank body 3 through the metering pump 2 to complete the configuration of the cleaning liquid in the tank body 3. The various pneumatic diaphragm valves 5 on the distributor 6 deliver the cleaning liquid to the pipelines and equipment that need to be cleaned. The operator controls the entire cleaning process through the man-machine interface 7 and the unit control cabinet 8.

[0031] The cleaning process of the pharmaceutical equipment in-place cleaning unit of the present invention has the following solutions:

[0032] In routine operation, the volume is fixed first, then pre-rinsed with purified water, then cyclically cleaned with cleaning solution, then finely washed with water for injection, then purged with clean compressed air, and finally sterilized with pure steam.

[0033] When self-cleaning, first rinse with purified water, then constant volume, then circulate cleaning with cleaning solution, then rinse with water for injection, then purify with clean compressed air, and finally sterilize with pure steam.

[0034] In the process of heating the cleaning liquid, the acid-base concentration is adjusted at the same time to save effective time. Different cleaning conditions use different cleaning temperatures and acid-base concentrations.

[0035] The above is merely an illustration to illustrate some principles of the present invention. This specification is not intended to limit the present invention to the specific structure and scope of application shown. Therefore, all corresponding modifications and equivalents that may be utilized are It belongs to the scope of the patent applied for by the present invention.

[0036] Except for the technical features described in the specification, the other technical features are all technologies known to those skilled in the art.

PUM

Property	Measurement	Unit
Thickness	50.0	mm
Surface finish	<= 0.41

Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

Improve work efficiency
Strong corrosion resistance

Clean-in-place unit of pharmaceutical equipment

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

Image

Examples

Example Embodiment

PUM

Description & Claims & Application Information

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