Medlar thirst-eliminating chewable tablet as well as preparation method and application thereof

A technology for chewing tablets and quenching thirst, which is applied in the field of medicine, can solve the problems of complex components of quenching thirst, sticking to tableting, difficulty in granulation, etc., and achieves the effects of improving taking compliance, good dispersion state and high bioavailability.

Active Publication Date: 2015-07-01
JINKE TIBETAN MEDICINE QINGHAI PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] No Goji Berry Xiaoke Chewable Tablets in the Prior Art
In addition, the thirst-quenching ingredients of wolfberry are complex, containing a large amount of polysaccharides, and there are many problems in the preparation process, such as high hygroscopicity, difficulty in granulation, sticky tableting, etc.

Method used

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  • Medlar thirst-eliminating chewable tablet as well as preparation method and application thereof
  • Medlar thirst-eliminating chewable tablet as well as preparation method and application thereof
  • Medlar thirst-eliminating chewable tablet as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0024] Experimental example 1, alcohol extraction process screening

[0025] According to the literature, flavonoids in seabuckthorn and hawthorn are one of the effective ingredients for lowering blood sugar. The extraction rate of flavonoids by traditional water decoction method is low. According to the physical and chemical properties of the flavonoids, the present invention decides to extract the flavonoids with ethanol. On the basis of the pre-experiment, determine the yield of dry extract and the content of total flavonoids as the investigation index, and use the orthogonal test to optimize the alcohol concentration, extraction time, alcohol addition amount, and extraction times. The design is shown in Table 1

[0026] Table 1 Alcohol extraction orthogonal test design table

[0027]

[0028] Weigh 22.5g of seabuckthorn and 37.5g of hawthorn according to the prescription amount, a total of 60g, take 9 parts, arrange the test according to the orthogonal table for reflu...

experiment example 2

[0035] Experimental example 2, crude polysaccharide preparation process screening

[0036] Lycium barbarum polysaccharides, yam polysaccharides, and astragalus polysaccharides have significant hypoglycemic effects, so polysaccharides are one of the main active ingredients of Lycium barbarum for quenching thirst. According to the physical and chemical properties of the crude polysaccharide, the present invention prepares the crude polysaccharide by water extraction and alcohol precipitation, and screens the alcohol precipitation process based on the yield and content of the crude polysaccharide.

[0037] Weigh 40g wolfberry fruit, 125g digupi, 135g yam, 65g malt, 115g astragalus according to the prescription ratio, add water and reflux to extract twice, add 10 times the amount for the first time, add 8 times the amount for the second time, and extract for 2 hours each time , combined the extracts, and concentrated under reduced pressure to 322g of a clear paste with a density o...

experiment example 3

[0044] Experimental Example 3, Excipient Screening of Chewable Tablets

[0045] 1. Screening of fillers and flavoring agents

[0046] The present invention is a chewable tablet, which needs to be chewed and swallowed after being crushed in the mouth, so the taste is very important. Mannitol is a common auxiliary material for chewable tablets. Its sweetness is about 70% of that of sucrose. Because of its heat-absorbing effect, it will feel very cool in the mouth, and there is no hard particle feeling when chewing. The characteristics of good compressibility can be used as a filler for chewable tablets; lactose has low hygroscopicity, good compression formability, the surface of the pressed tablet is bright and beautiful, and the dissolution rate of the drug is good. 5. Therefore, the present invention uses mannitol and lactose as fillers and sweeteners. In addition, the taste of the traditional Chinese medicine extract is complicated, and it is difficult to adjust a good tast...

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PUM

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Abstract

The invention relates to a Chinese wolfberry Xiaoke chewable tablet, a preparation method and application thereof. The chewable tablet is composed of the following raw materials: 40-50 parts by weight of alcohol extract, 40-50 parts by weight of alcohol-precipitated water extract, 75-80 parts by weight of crude polysaccharide, 300-400 parts by weight of filler, 1-5 parts by weight of Flavoring agent and 10-20 parts by weight of lubricant; the present invention carries out a large number of tests with mouthfeel, preparation forming process characteristics and the appearance of gained chewable tablet etc. as index, selects suitable filler, flavoring agent and lubricant and preparation process , to make chewable tablets with better mouthfeel, improve the compliance of taking, and improve the curative effect of the medicine. The invention also discloses the application of the wolfberry Xiaoke chewable tablet in the preparation of drugs for treating type II diabetes and its complications.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its preparation method and application, in particular to a wolfberry Xiaoke chewable tablet and its preparation method and application, belonging to the technical field of medicine. Background technique [0002] Lycium barbarum Xiaoke Capsules is recorded in the national drug standard part of the rising local standard of Chinese patent medicine, standard number: WS-10701 (ZD-0701)-2002, the prescription is as follows: fresh seabuckthorn 110g, fresh wolfberry 160g, Digupi 125g, hawthorn 50g, Yam 135, malt 65g, astragalus 115g, made into 1000 capsules. The traditionally prepared wolfberry Xiaoke capsule mainly contains: freeze-dried powder of fresh seabuckthorn and fresh wolfberry fruit and spray-dried powder of water extracts of other medicinal materials. The preparation method is as follows: fresh seabuckthorn is compressed and concentrated, and then freeze-dried into powder; fresh medlar is cr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8998A61K9/20A61K47/26A61K47/12A61K47/10A61K47/04A61P3/10
Inventor 李丽李怀平姬涛王朔王海苹
Owner JINKE TIBETAN MEDICINE QINGHAI PROV
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