Preparation method of resin catalyst for synthesis of difluoromethyl ether

Abstract

The invention provides a preparation method of a resin catalyst for synthesis of difluoromethyl ether. Strong basic anion-exchange resin is prepared by reacting chloromethylated polystyrene with perfluorinated octyl sulfonamide and trimethylamine simultaneously. The resin catalyst comprises a mixture of the quaternary ammonium salt of perfluorinated octyl sulfonamide and the quaternary ammonium salt of the trimethylamine. A fluorine element and a sulfonamide group are introduced, so the compatibility of the catalyst and a fluorine-containing raw material can be improved, an amino group is unlikely to drop off, and the yield of the difluoromethyl ether is increased.

Description

technical field [0001] The invention relates to a method for preparing a catalyst, in particular to a method for preparing a resin catalyst for synthesizing difluoromethyl ether. Background technique [0002] Difluoromethyl ether, also known as bis(difluoromethyl)ether, is synthesized by chlorinating dimethyl ether, then separating it, and finally fluorinating bis(dichloromethyl)ether. A disadvantage of this prior art is that the chlorination step yields a complex mixture of various chlorinated dimethyl ethers, some of which are unstable, so that the bis(dichloromethyl)ether is difficult to recover efficiently by distillation. Due to the unique properties of fluorine atoms, a large number of facts show that the introduction of difluoromethyl groups into molecules can often effectively improve the physiological activity of organic molecules. Therefore, compounds containing difluoromethyl have been paid more and more attention in the fields of medicine, pesticides and materia...

AI Technical Summary

Problems solved by technology

This patent uses a basic ion exchange resin as a solid base catalyst, because the hydroxyl group of the basic ion exchange resin is easy to fall off, and the service life and application times of the catalyst are affected

[0005] The catalysts used in the above known technologies all have the problem that they are not easy to separate, or cannot be used in multiple batches for a long time, which affects the use effect in industrial devices

Images