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Application of a traditional Chinese medicine composition in the preparation of medicines for the treatment of oxidative stress in diabetes

A composition and diabetes technology, applied in the direction of drug combination, pharmaceutical formula, metabolic diseases, etc., can solve problems such as selection, dosage, course of treatment, and site of action to be further studied

Active Publication Date: 2018-12-07
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antioxidant therapy can reduce oxidative stress, thereby preventing or delaying the occurrence and development of diabetes and its complications. However, the selection, dosage, course, and site of action of antioxidative therapy drugs need further research

Method used

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  • Application of a traditional Chinese medicine composition in the preparation of medicines for the treatment of oxidative stress in diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1: Preparation of pharmaceutical capsules of the present invention

[0052] prescription:

[0053] 180 grams of red peony root, 330 grams of astragalus, 180 grams of Radix Rehmanniae, 170 grams of Puhuang, 180 grams of Ligustrum lucidum, 230 grams of Eclipta prostrata, 280 grams of Ginkgo biloba, 130 grams of rhubarb, 80 grams of Panax notoginseng, 130 grams of Dilong, Cassia seed 280 grams, Pueraria lobata 230 grams.

[0054] Preparation:

[0055] (1) Weigh the Puhuang according to the prescription, use 6 times 70% ethanol as the solvent, first soak the medicinal material with an appropriate amount of solvent, seal it for 15 minutes, install the percolation column, add the remaining solvent to soak for 24 hours, percolate, and collect the percolation. Liquid, spare;

[0056] (2) Weigh out the raw rehmannia and earthworm according to the prescribed amount, add 9 times the amount of water for the first time, soak for 20 minutes, heat and decoct for 1.5 hours, and filter;...

Embodiment 2

[0062] Example 2: Preparation of pharmaceutical tablets of the present invention

[0063] prescription:

[0064] Red peony 230g, Astragalus 280g, Rehmannia glutinosa 230g, Puhuang 130g, Ligustrum lucidum 230g, Eclipta prostrata 180g, Ginkgo biloba 330g, Rhubarb 80g, Panax notoginseng 130g, Dilong 80g, Cassia seed 330 grams, Pueraria lobata 180 grams.

[0065] Preparation:

[0066] (1) Weigh the Puhuang in proportion, use 5 times the amount of 75% ethanol as the solvent, first soak the medicinal materials with an appropriate amount of solvent, seal it for 20 minutes, install the percolation column, add the remaining solvent to soak for 27 hours, and use about 3ml / kg / Percolate at the speed of min, collect the percolate and reserve;

[0067] (2) Weigh out raw rehmannia glutinosa and earthworms in proportion, add 9 times the amount of water for the first time, soak for 15 minutes, heat and cook for 1.5 hours, and filter; add 7 times the amount of water for the second time, decocting for ...

Embodiment 3

[0073] Example 3: Preparation of the pharmaceutical oral liquid of the present invention

[0074] prescription:

[0075] 200 grams of red peony root, 300 grams of astragalus, 200 grams of rehmannia glutinosa, 150 grams of cattail yellow, 200 grams of Ligustrum lucidum, 200 grams of Eclipta prostrata, 300 grams of ginkgo biloba, 100 grams of rhubarb, 100 grams of Panax notoginseng, 100 grams of ground dragon, 300 grams of cassia seed and 200 grams of kudzu root.

[0076] Preparation method: Oral liquid is prepared according to the conventional preparation method.

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparing a medicine for treating oxidative stress in diabetes. The traditional Chinese medicine composition of the present invention is composed of 12 traditional Chinese medicines such as Radix Paeoniae Rubra, Radix Astragali, Rehmannia Root, etc., which can remove blood stasis and dredge collaterals, nourish qi and nourish yin. Clinical studies have shown that the traditional Chinese medicine composition of the present invention can effectively treat oxidative stress in diabetes.

Description

Technical field [0001] The invention relates to a new use of a traditional Chinese medicine composition, in particular to the application of a traditional Chinese medicine composition in the preparation of a medicine for the treatment of oxidative stress in diabetes. Background technique [0002] Oxidative Stress (Oxidative Stress, OS) refers to the imbalance between oxidation and anti-oxidation in the body, which tends to oxidize, leading to inflammatory infiltration of neutrophils, increased secretion of proteases, and the production of a large number of oxidative intermediate products. Oxidative stress is a negative effect produced by free radicals in the body, and is considered to be an important factor leading to aging and disease. The production of oxidative stress in the body is mainly due to the increase in the production of free radicals and / or damage to the antioxidant defense function. Dr. Brownlee believes that high blood glucose levels in diabetes inhibit the mitoch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88A61K9/48A61P3/10A61P39/06
Inventor 齐晓琳高学东张会欣王宏涛杜彦霞谷春华许红辉孙利杨立波张秋艳张永锋
Owner SHIJIAZHUANG YILING PHARMA
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