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Application of traditional Chinese medicine composition to prepare medicaments for treating diabetes oxidative stress

A composition and diabetes technology, applied in the direction of drug combination, pharmaceutical formula, metabolic diseases, etc., can solve problems such as selection, dosage, course of treatment, and site of action to be further studied

Active Publication Date: 2014-03-12
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antioxidant therapy can reduce oxidative stress, thereby preventing or delaying the occurrence and development of diabetes and its complications. However, the selection, dosage, course, and site of action of antioxidative therapy drugs need further research

Method used

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  • Application of traditional Chinese medicine composition to prepare medicaments for treating diabetes oxidative stress

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: the preparation of medicine capsule of the present invention

[0052] prescription:

[0053] 180 grams of red peony, 330 grams of astragalus, 180 grams of raw rehmannia, 170 grams of Puhuang, 180 grams of Ligustrum lucidum, 230 grams of Eclipta, 280 grams of ginkgo leaves, 130 grams of rhubarb, 80 grams of Sanqi, 130 grams of earthworm, 280 grams of cassia seeds and 230 grams of kudzu root.

[0054] Preparation:

[0055] (1) Weigh Puhuang according to the prescription amount, use 6 times the amount of 70% ethanol as the solvent, soak the medicinal material with an appropriate amount of solvent, seal it for 15 minutes, install the percolation column, add the remaining solvent to soak for 24 hours, percolate, and collect the percolation column. wet liquid, spare;

[0056] (2) Weigh raw rehmannia and earthworm according to the prescription amount, add 9 times the amount of water for the first time, soak for 20 minutes, heat and decoct for 1.5 hours, filter...

Embodiment 2

[0062] Embodiment 2: the preparation of pharmaceutical tablet of the present invention

[0063] prescription:

[0064] 230 grams of red peony, 280 grams of astragalus, 230 grams of rehmannia, 130 grams of Puhuang, 230 grams of Ligustrum lucidum, 180 grams of Eclipta, 330 grams of ginkgo leaves, 80 grams of rhubarb, 130 grams of Sanqi, 80 grams of earthworm, 330 grams of cassia seeds and 180 grams of kudzu root.

[0065] Preparation:

[0066] (1) Weigh Puhuang according to the proportion, use 5 times the amount of 75% ethanol as the solvent, first soak the medicinal material with an appropriate amount of solvent, seal it for 20 minutes, install the percolation column, add the remaining solvent to soak for 27 hours, and use about 3ml / kg / min speed percolation, collect the percolation liquid and set it aside;

[0067] (2) Weigh raw rehmannia and earthworm in proportion, add 9 times the amount of water for the first time, soak for 15 minutes, heat and decoct for 1.5 hours, filt...

Embodiment 3

[0073] Embodiment 3: the preparation of medicament oral liquid of the present invention

[0074] prescription:

[0075] 200 grams of red peony, 300 grams of astragalus, 200 grams of rehmannia, 150 grams of Puhuang, 200 grams of Ligustrum lucidum, 200 grams of Eclipta, 300 grams of ginkgo leaves, 100 grams of rhubarb, 100 grams of Panax notoginseng, 100 grams of earthworm, 300 grams of cassia seeds and 200 grams of kudzu root.

[0076] Preparation method: make oral liquid according to conventional preparation methods.

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Abstract

The invention discloses application of a traditional Chinese medicine composition to prepare medicaments for treating diabetes oxidative stress. The traditional Chinese medicine composition is composed of twelve traditional Chinese medicines such as radix paeoniae rubrathe, radix astragali, raw rehmannia root and the like, and has the functions of resolving stasis, freeing collateral vessels, tonifying qi and tonifying yin; and clinical research shows that the traditional Chinese medicine composition is capable of effectively treating diabetes oxidative stress.

Description

technical field [0001] The present invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition in the preparation of a drug for treating oxidative stress in diabetes. Background technique [0002] Oxidative stress (OS) refers to the imbalance between oxidation and anti-oxidation in the body, which tends to oxidize, leading to inflammatory infiltration of neutrophils, increased secretion of proteases, and production of a large number of oxidized intermediates. Oxidative stress is a negative effect of free radicals in the body and is believed to be an important factor in aging and disease. Oxidative stress in the body is mainly due to increased production of free radicals and / or damage to antioxidant defense functions. Dr. Brownlee believes that the high concentration of blood sugar in diabetes inhibits the mitochondrial electron transfer chain, and when the terminal link i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K9/48A61P3/10A61P39/06
Inventor 齐晓琳高学东张会欣王宏涛杜彦霞谷春华许红辉孙利杨立波张秋艳张永峰
Owner SHIJIAZHUANG YILING PHARMA
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