Preparation method of glucan embolism microspheres with CT (computed tomography) visualization function

Abstract

The invention relates to a preparation method of glucan embolism microspheres with a CT (computed tomography) visualization function. The preparation method is characterized by comprising the steps of dissolving polymethyl vinyl ether maleic anhydride grafted with beta-CD and modified glucan in water; uniformly stirring and then dropwise adding the solution into dimethyl silicone oil, wherein the volume ratio of a water phase to an oil phase is 1:5; under the condition of magnetic stirring, heating to 60-120 DEG C to react for 16-48 hours; after the reaction, standing and then removing supernatant fluid; cleaning microspheres deposited at the bottom of a container by using n-hexane; removing the remaining dimethyl silicone oil; and performing vacuum drying to remove the n-hexane on the surface to obtain gel microspheres with the particle size of 30+/-5 microns and good dimensional homogeneity. The gel microspheres are added into a developer iodine solution or iodized oil, and the microspheres are discovered to have an obvious gray level through micro-CT observation.

Description

technical field [0001] The present invention relates to a method for preparing dextran embolization microspheres, in particular to a method for preparing dextran microspheres by reverse suspension polymerization. The obtained microspheres have the function of CT imaging and can be used for clinical arterial embolization treatment . Background technique [0002] Dextran is a natural non-animal oligosaccharide with glucose as the monosaccharide. It has a wide range of sources, is cheap, can be degraded by enzymes, can be used as a material for cell culture, and has good biocompatibility. β-cyclodextrin has a bowl-like structure, its large bowl is lipophilic, and the small bowl is hydrophilic, so it can be used as a carrier of iodine oil or iodine solution, and then realize CT imaging (Release Characteristics of Iodine Encapsulated in Cyclodextrins, Department of Biotechnology, Tottori University, 4-101 Koyamacho-minami, 680-8552, Tottori, Japan). Polymethyl vinyl ether malei...

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Problems solved by technology

[0003] There are currently four types of embolization consumables for transcatheter vascular embolization on the market: 1. Sponge embolization consumables, such as: gelatin sponge and polyvinyl alcohol. Among them, gelatin sponge belongs to short-term embolization consumables and is easily absorbed by the body; Long-term embolization consumables mainly rely on imports and are expensive; 2. Liquid embolization consumables, such as: absolute ethanol, sodium morrhuate, super-liquefied lipiodol, and Pingyangmycin lipiodol emulsion. After the human body, it reacts with tissues and causes serious damage to human tissues; cod liver oil sodium is a long-term embolization consumable, but it can only be applied to thicker blood vessels; super liquefied lipiodol is a short-term embolization consumable, which is easy to be absorbed by the body; Pingyangmycin lipiodol Emulsions are medium-term embolization consumables, containing radioactive substa

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