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Polyurethane heparinized coating solution and preparation method thereof

A polyurethane emulsion and coating liquid technology, applied in polyurea/polyurethane coatings, heparin coatings, coatings, etc., can solve problems such as side effects, increased heparin dosage, and functional impairment, and achieve good biocompatibility and reduce additives The effect of increasing the amount and dosage

Active Publication Date: 2016-03-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But unfortunately, on the one hand, the activity of heparin will decrease after the complex is formed, which will increase the amount of heparin, which will not only increase the cost, but also cause the decrease of the number of human platelets and the function of blood platelets. damage and other side effects. On the other hand, the introduction of organic solvents not only increases the cost of preparation and disposal of emissions, but also the difficulty of removing organic solvents in products also limits their popularization and application.

Method used

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  • Polyurethane heparinized coating solution and preparation method thereof
  • Polyurethane heparinized coating solution and preparation method thereof
  • Polyurethane heparinized coating solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) First add 5 parts of polycaprolactone diol and 1.208 parts of polyethylene glycol into the reaction vessel to evacuate and heat to 75°C for dehydration for 1 hour, then add 2.22 parts of isophorone diisocyanate isophorone diisocyanate And 0.03 parts of organic bismuth, prepolymerized at 73 ° C for 1 h.

[0035] (2) Dissolve 0.827 parts of L-lysine in 47 parts of water, then add the above prepolymer under high-speed stirring, and then add NaOH solution to adjust the pH of the emulsion to 7.0 to obtain a water-based non-toxic product with a solid content of 20%. polyurethane emulsion.

[0036] (3) Prepare heparin sodium with a weight-average molecular weight of 6000-20000 into a solution with a concentration of 1g / L, and then, under the action of ultrasonic waves with a power of 140w, mix it evenly with water-based non-toxic polyurethane emulsion in the same volume to obtain a polyurethane heparinized coating Liquid I. Wherein the mass ratio of heparin and polyureth...

Embodiment 2

[0038] (1) First add 4.66 parts of polycaprolactone diol and 1.45 parts of polyethylene glycol into the reaction vessel to evacuate and heat to 80°C for dehydration for 1 hour, then add 2.14 parts of isophorone diisocyanate and 0.03 parts of stannous octoate , Prepolymerization at 75°C for 1h.

[0039](2) Dissolve 0.826 parts of L-lysine and 0.11 parts of heparin sodium with a weight average molecular weight of 6000-20000 in 35 parts of water, then add the above prepolymer under high-speed stirring, and then add NaOH solution to adjust the pH of the emulsion to 7.0, that is, the solid content is 25% water-based non-toxic polyurethane heparinized coating solution II. Wherein the mass ratio of heparin and polyurethane is 1.2%.

Embodiment 3

[0041] (1) First add 5 parts of polycaprolactone diol and 1.208 parts of polyethylene glycol into the reaction vessel to evacuate and heat to 80°C for dehydration for 2 hours, then add 2.22 parts of lysine diisocyanate, 0.45 parts of 1,4- Butylene glycol and 0.03 parts of organic bismuth were prepolymerized at 72°C for 1 hour.

[0042] (2) Dissolve 0.827 parts of L-lysine in 32 parts of water, then add the above prepolymer under high-speed stirring, and then add NaOH solution to adjust the pH of the emulsion to 7.0 to obtain a water-based non-toxic product with a solid content of 30%. polyurethane emulsion.

[0043] (3) Prepare heparin lithium with a weight-average molecular weight of 6000-20000 into a solution with a concentration of 9g / L, and then blend it with water-based non-toxic polyurethane emulsion in the same volume under stirring to obtain polyurethane heparinized coating liquid III . Wherein the mass ratio of heparin and polyurethane is 3%.

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Abstract

The invention discloses a heparinized polyurethane coating liquid. The coating liquid is characterized by being prepared from a waterborne polyurethane solution and a heparin water solution in a blending manner, wherein the mass ratio of heparin to polyurethane in the coating liquid is 0.5-10%. The invention also discloses a preparation method of the coating liquid. The heparinized polyurethane coating liquid provided by the invention not only adopts the waterborne non-toxic polyurethane solution which is good in biocompatibility, and does not cause conglutination and activation of blood platelets, but also can directly dissolve the heparin, is small in effect on erythrocyte, low in hemolysis ratio, and free of cytotoxicity in use, and can solve the problem of blending of the heparin and the polyurethane in the prior art, the adding amount of the heparin is reduced, the cost of the coating liquid is reduced, kinds of defects caused by an organic solvent used in the prior art are avoided, and meanwhile, the antimicrobial efficacy is also provided. The preparation method is simple in technology, environment-friendly, safe, and low in cost, and can achieve large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of biological and medical polyurethane materials and their preparation, and in particular relates to a polyurethane heparinized coating solution and a preparation method thereof. Background technique [0002] With the development of science and technology and social needs, more and more medical materials are used clinically, such as artificial heart, artificial blood vessel, artificial kidney and artificial lung. However, it is well known that ordinary medical materials are poorly compatible with blood, which can cause blood coagulation when in contact with blood, which limits the clinical use of these artificial organs. [0003] Due to its good mechanical properties, biocompatibility and molecular tailorability, polyurethane is considered to be an ideal biomaterial, which can be used for artificial blood vessels, heart valves and drug carriers. As artificial blood vessels and heart valves, they must not on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09D175/04C09D105/10C09D5/14A61L33/10A61L33/06
Inventor 谭鸿李洁华高云龙傅强张怡
Owner SICHUAN UNIV
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