82results about "Heparin coatings" patented technology

The present invention relates to processes utilizing ionic liquids for the dissolution of various polymers and / or copolymers, the formation of resins and blends, and the reconstitution of polymer and / or copolymer solutions, and the dissolution and blending of “functional additives” and / or various polymers and / or copolymers to form advanced composite materials.

A solid surface material with an antimicrobial agent in a thermoset and / or thermoplastic resin matrix where the antimicrobial agent comprises a chitosan-metal complex.

The invention provides a network composition comprising a plurality of associated saccharide chains wherein a chain comprises at least one saccharide component; and at least one first monomer, at least one second monomer, or combinations of both; wherein the first monomer is linked to the saccharide component by ester linkages; ether linkages; amide linkages; ketone linkages; or combinations thereof; wherein the second monomer is linked to the saccharide component by ester linkages; ether linkages; amide linkages; ketone linkages; urea linkages; carbamate linkages, aluminum oxide linkages; siloxane linkages; or combinations thereof; wherein first monomers are linked to each other by ester linkages; ether linkages; amide linkages; ketone linkages; or combinations thereof; wherein the first monomer is linked to the second monomer by ester linkages; ether linkages; amide linkages; ketone linkages; urea linkages; carbamate linkages; aluminum oxide linkages; siloxane linkages or combinations thereof; wherein the second monomers are linked to each other by ester linkages; ether linkages; amide linkages; ketone linkages; polyvinyl linkages, polyolefin linkages, urea linkages; carbamate linkages, aluminum oxide linkages, siloxane linkages or combinations thereof; and wherein the saccharide components are linked to each other by ester linkages; ether linkages; amide linkages; ketone linkages; or combinations thereof; wherein the network is capable of adhering to a substrate.

The present invention provides methods of preventing the flow of water or gas or both through a subterranean zone having a high temperature and a depth such that a long pumping time is required to place a sealing composition therein. The methods basically comprise the steps of preparing a polymeric sealing composition comprised of water, a cross-linking agent and a selected water-soluble polymer which reacts with the cross-linking agent and forms a sealing gel which is stable for a desired period of time at the temperature of the zone and has a pumping time before gelation in the presence of the cross-linking agent whereby the composition can be pumped to the depth of the zone and placed therein. Thereafter, the sealing composition is pumped into the zone and allowed to form a sealing gel therein.

The present application discloses methods for repairing hyaline cartilage defects. The methods comprise a combination of introducing autologous bone mesenchymal stem cells to a joint, and applying to the joint a membrane comprising a polyester entangled with a polysaccharide. In some aspects, the bone mesenchymal stem cells are mesenchymal stem cells originating in bone underlying the joint. In these aspects, contact between the joint and the mesenchymal stem cells can be effected by introducing apertures through the bone using standard surgical techniques such as microfracture, abrasion, or drilling. Cartilage which forms in response to application of these methods is hyaline cartilage rather than fibrocartilage.

Water-based, substrate treatment compositions contain (A) at least one chitosan selected from chitosan and a chitosan derivative, and (B) a metal compound containing at least one metal selected from Ti, Zr, Hf, Mo, W, Se, Ce, Fe, Cu, Zn, V and trivalent Cr. In particular, the water-based, substrate treatment compositions can improve the interlayer adhesion between metal materials and resin coating layers such as films or coatings, and can also improve the corrosion resistance and solvent resistance of such metal materials.

The present invention relates to processes utilizing ionic liquids for the dissolution of various polymers and / or copolymers, the formation of resins and blends, and the reconstitution of polymer and / or copolymer solutions, and the dissolution and blending of “functional additives” and / or various polymers and / or copolymers to form advanced composite materials.

The invention is directed to a method and composition for providing chemically-resistant roughened copper surfaces suitable for subsequent multilayer lamination. In one embodiment, a smooth copper surface is contacted with an adhesion promoting composition under conditions effective to provide a roughened copper surface, the adhesion promoting composition comprising an oxidizer, a pH adjuster, a topography modifier, and a sulfur-containing coating stabilizer. In another embodiment, a smooth copper surface is contacted with an adhesion promoting composition under conditions effective to provide a roughened copper surface, the adhesion promoting composition comprising an oxidizer, a pH adjuster, and a topography modifier. Then, in a subsequent step, the roughened copper surface is contacted with an acid resistance promoting composition.

A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or DEAE-Dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying pressure. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the solidified matrix cross-linked and integrated at the wound site, including the methods of using, applying, and cross-linking the composition.

A water-based slurry composition contains (1) a water-based medium containing at least water as a polar solvent, (2) at least one polymer selected from cellulose derivatives, alginic acid derivatives, starch derivatives, chitin derivatives, chitosan derivatives, polyallylamine and polyvinylamine, (3) a hydrophobic filler, and (4) a polybasic acid or a derivative thereof. The composition has a water content of 30 mass % or higher. An electrode plate for an electricity storage device, and the electricity storage device are also disclosed.

The invention provides polyelectrolyte hydrogels, blends, and multilayers for the controlled release of bioactive agents from implantable medical devices coated with or containing such media.

A nucleic acid coating composition including a polyanion bound, directly or through one or more intermediates, to a medical device surface, with a condensate comprising a polycation and nucleic acid bound to the polyanion, devices incorporating such coating compositions, and methods for making. In one embodiment, a silyl-heparin complex is provided, bound to a medical device surface by hydrophobic interaction with the silyl moiety, with a polycation and nucleic acid condensate bound to the heparin by electrostatic interaction.

An electrode sensor kit for establishing electrical contact with skin comprises at least one contact element and a preparation comprising a mixture of water and at least one lipid for enhancing electrical contact properties between said contact element and the skin, wherein said mixture forms an emulsion, in particular a water-in-oil or an oil-in-water emulsion, having a conductivity of less than 3 mS / cm. An electrode assembly for electrical impedance tomography which comprises said kit is characterized in that (a) said at least one contact element forms an electrode or sensor plate, and (b) said at least one contact element comprises a layer of said preparation.

A solid surface material with an antimicrobial agent in a thermoset and / or thermoplastic resin matrix where the antimicrobial agent comprises a chitosan-metal complex.

A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Water-based, substrate treatment compositions contain (A) at least one chitosan selected from chitosan and a chitosan derivative, and (B) a metal compound containing at least one metal selected from Ti, Zr, Hf, Mo, W, Se, Ce, Fe, Cu, Zn, V and trivalent Cr. In particular, the water-based, substrate treatment compositions can improve the interlayer adhesion between metal materials and resin coating layers such as films or coatings, and can also improve the corrosion resistance and solvent resistance of such metal materials.

A colored particle (e.g., a spherical particle) comprising an organic solid component (e.g., a polymer component) and a coloring agent (e.g., an oil-soluble dye, and an organic or inorganic pigment) is produced by eluting a water-soluble auxiliary component comprising at least an oligosaccharide from a composition having a disperse system, in which a particulate dispersed phase comprising the organic solid component and the coloring agent is dispersed in a matrix comprising the auxiliary component. The weight ratio of the polymer component relative to the auxiliary component may be about 55 / 45 to 1 / 99. The proportion of the coloring agent may be about 0.001 to 100 parts by weight relative to 100 parts by weight of the organic solid component. Such a process ensures conveniently and industrially advantageous production of a colored particle (e.g., a colored polymer particle) corresponding to the dispersed phase independently of affinity between the dispersed phase and the matrix.

The invention relates to a polymer composition comprising a biologically degradable polymer and a material from sea plants and / or shells of sea animals or at least two components selected from the group consisting of saccharides and the derivatives thereof, proteins, amino acids, vitamins and metal ions. The invention additionally relates to a molded article comprising said polymer composition. Said molded article may be used packaging material or fibrous material, in the form of fibrous material as mixing component for the production of yarns, and in the form of fibrous material for the production of nonwoven fabrics or woven fabrics.

The present application discloses methods for repairing hyaline cartilage defects. The methods comprise a combination of introducing autologous bone mesenchymal stem cells to a joint, and applying to the joint a membrane comprising a polyester entangled with a polysaccharide. In some aspects, the bone mesenchymal stem cells are mesenchymal stem cells originating in bone underlying the joint. In these aspects, contact between the joint and the mesenchymal stem cells can be effected by introducing apertures through the bone using standard surgical techniques such as microfracture, abrasion, or drilling. Cartilage which forms in response to application of these methods is hyaline cartilage rather than fibrocartilage.

Disclosed is a foaming material composite including a water-soluble polysaccharide having ester linkage or amide linkage, a foaming agent, and a plasticizing agent.

A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said polymer blend. The second polymer may be selected from the group consisting of polyether glycols including polyethylene glycols; cellulose esters including cellulose acetate; poloxamers; polysaccharides including dextran and guar; polyvinylpyrrolidones; polyvinyl alcohols; and mixtures or copolymers thereof. These polymer blends swell in an acidic environment and deswell in a more neutral or basic environment. This technology is valuable for the dispensing of biologically active material or drugs into a surrounding environment, especially the environment as is found in the gastrointestinal tract. Since the various polymer blends of the present invention are not covalently or ionically crosslinked, but are physically combined, each polymer in the physical blend maintains its original chemical structure, and therefore, is safe for oral administration.

Disclosed is a cellulose ester film which is suppressed in volatilization of components during film formation, while having high surface flatness, high durability after saponification and good adhesion to a polarizer. Also disclosed is a method for producing such a cellulose ester film by melt forming. Further disclosed are a polarizing plate having high light resistance and high durability, and a liquid crystal display having high image quality. Specifically disclosed is a cellulose ester film characterized by containing a cellulose ester, a compound represented by the general formula (1) below, and a compound represented by the general formula (2) below.

The invention provides compositions and methods for in situ repair of compromised polymeric membranes. The invention is useful for repairing compromised polymeric membranes without requiring the knowledge of damage location or the disassembly of a system. The invention relates to preferential blocking of damaged sites using agglomerates and subsequent cross-linking to form sturdy plugs.

The present invention relates to a composite including chitosan and / or chitin and a catechol-based compound, an organic reinforcing material composition including the composite, a product manufactured by using the organic reinforcing material composition, and a method for preparing a chitosan and / or chitin composite with improved strength, including the step of adding the catechol-based compound to chitosan and / or chitin. The chitosan and / or chitin composite including the catechol-based compound is advantageous in that it is able to maintain high strength in a wet-swollen state by improving the problem of strength reduction due to moisture, compared to the composites containing no catechol-based compound.

The present invention provides anti-thrombogenic compositions, including anti-thrombogenic vascular grafts. In certain embodiments, the compositions comprise decellularized tissue coated with an anti-thrombogenic coating. The present invention also provides methods of preparing anti-thrombogenic compositions and methods of treatment comprising implanting the anti-thrombogenic compositions into a subject in need thereof.

Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a poly(hydroxyalkanoate).

This invention relates to a cross-linkable chitosan composition comprising chitosan having a degree of deacetylation between 30 and 75%, wherein the chitosan is randomly deacetylated, and a cross-linking agent, wherein the molar ratio of the cross-linking agent to chitosan is 0.2:1 or less based on the number of functional groups in the cross-linking agent and the number of accessible amino groups in the chitosan. The invention also provides a chitosan hydrogel formed therefrom and uses thereof.

Binder including (i) a chitosan derivative and (ii) deionized water or 1 vol. % aqueous solution of acetic acid as a dispersant. A method for preparing an electrode of a lithium ion battery by adding the binder to a conductive agent.