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Buddleja officinalis granules and preparation method thereof

A technology of Budisma japonica and granules, which is applied in the direction of medical formulas, medical preparations containing active ingredients, block delivery, etc., can solve the problems of unfavorable patients taking and carrying, many compatibility, troublesome decoction, etc., and improve compliance Sexuality, abundant resources and low price

Inactive Publication Date: 2014-04-30
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinically used traditional Chinese medicine prescriptions have many medicinal materials, and it is troublesome to decoct, which is not conducive to patients' taking and carrying.

Method used

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  • Buddleja officinalis granules and preparation method thereof
  • Buddleja officinalis granules and preparation method thereof
  • Buddleja officinalis granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] A kind of Mimenghua granule formula:

[0066] Buddies 20kg

[0067] water 500kg

[0068] Lactose 2.298kg

[0069] Preparation Process:

[0070] 1. Extraction of the original medicinal material: take 20kg of crushed granules of the original medicinal material of Mimenghua, add 15 times the amount of water (300kg) for the first time, soak for 1.5 hours, reflux extraction for 1.5 hours, and add 10 times the amount of water (200kg) for the second time for reflux extraction 1.0 hours.

[0071] 2. Concentration and drying of the extract: Concentrate the water extract of Budisma japonica to about 20,000ml under reduced pressure, and spray-dry the concentrated solution (at a temperature of 180°C) to obtain 3.172kg of extract powder, with an extract yield of 15.86%.

[0072] 3. Dilution and mixing: Weigh 3.172kg of Mimenghua water extract powder, add 2.298kg of diluent lactose, grind and mix until the color is uniform.

[0073] 4. Making soft material: Spray 5% PVP alcohol ...

Embodiment 2

[0078] A kind of Mimenghua granule formula:

[0079] Buddies 30kg

[0080] water 450kg

[0081] Lactose 2.5kg

[0082] Preparation Process:

[0083] 1. Extraction of raw medicinal materials: take 30kg of pulverized granules of the original medicinal materials of Mimenghua, add 10 times the amount of water (300kg) for the first time, soak for 2 hours, reflux extraction for 1.5 hours, and add 5 times the amount of water (150kg) for reflux extraction for the second time 1.5 hours. (mass ratio)

[0084] 2. Concentration and drying of the extract: Concentrate the water extract of Budisma japonica to about 18,000ml under reduced pressure, and spray-dry the concentrated solution (at a temperature of 150°C) to obtain 2.855kg of extract powder, with an extract yield of 15.86%.

[0085] 3. Dilution and mixing: Weigh 2.855kg of Mimenghua water extract powder, add 2.5kg of diluent lactose, grind and mix until the color is uniform.

[0086] 4. Making soft material: Spray 7% PVP alcoh...

Embodiment 3

[0091] A kind of Mimenghua granule formula:

[0092] Buddies 12kg

[0093] water 180kg

[0094]Lactose 1.5kg

[0095] Preparation Process:

[0096] 1. Extraction of raw medicinal materials: Take 12kg of pulverized granules of the original medicinal material of Mimenghua, add 10 times the amount of water (120kg) for the first time, soak for 2 hours, reflux extraction for 1.5 hours, and add 5 times the amount of water (60kg) for reflux extraction for the second time 1.5 hours. (mass ratio)

[0097] 2. Concentration and drying of the extract: Concentrate the water extract of Budisma japonica to about 7200ml under reduced pressure, and spray-dry the concentrated solution (at a temperature of 180°C) to obtain 1.142kg of extract powder, with an extract yield of 15.86%.

[0098] 3. Dilution and mixing: Weigh 1.142kg of water-extracted extract powder of Budisma japonica, add 1.5kg of diluent lactose, grind and mix until the color is uniform.

[0099] 4. Making soft material: Spr...

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Abstract

The invention discloses buddleja officinalis granules and a preparation method thereof. The buddleja officinalis granules disclosed by the invention are prepared from the following raw materials in parts by weight: 10-50 parts of buddleja officinalis, 100-500 parts of water, and 1-5 parts of lactose. The buddleja officinalis granules prepared by the invention have the effects of clearing heat and improving eyesight and can be used for treating xerophthalmia. The invention further discloses a preparation method of the buddleja officinalis granules. The preparation method disclosed by the invention is simple in process and is applied to large-scale industrial production. The pharmacodynamic experiment results show that the buddleja officinalis granules prepared by using the preparation method disclosed by the invention have the effect of preventing and treating xerophthalmia. The buddleja officinalis granules disclosed by the invention have the advantages of simple preparation method, accurate curative effect and low cost; enormous social benefits and economic benefits are expected to generate.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a Mimenghua granule for treating dry eye and a preparation method thereof. technical background [0002] Dry eye, also known as keratoconjunctivitis sicca, refers to the abnormal tear quality or quantity caused by any reason, or the decrease in tear film stability caused by abnormal dynamics, accompanied by eye discomfort and (or ) A general term for various diseases characterized by ocular surface tissue lesions. Dry eye is a common ocular surface disease, mostly in both eyes. Epidemiological and clinical studies have found that its incidence is much higher than people imagined. Among them, the incidence rate of women is higher than that of men, and the incidence rate of contact lens wearers is significantly higher than that of non-contact lens wearers. According to a survey in the United States, 14.6% of people aged 65 to 84 suffer from dry eye syndrom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/56A61K9/16A61P27/02
Inventor 彭清华欧阳云彭俊姚小磊何群
Owner HUNAN UNIV OF CHINESE MEDICINE
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