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Encapsulated emamectin benzoate microspheres and preparation method thereof

A technology of emamectin and benzoate, which is applied in the field of pesticides to achieve the effects of avoiding repeated use of pesticides, reducing pollution and high efficacy

Inactive Publication Date: 2014-06-04
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to overcome the deficiencies in the prior art, provide a kind of emamectin benzoate microspheres and its encapsulation efficiency higher Preparation method, to solve the problem that the encapsulation efficiency of traditional emamectin benzoate microcapsule preparation method is not high

Method used

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  • Encapsulated emamectin benzoate microspheres and preparation method thereof
  • Encapsulated emamectin benzoate microspheres and preparation method thereof
  • Encapsulated emamectin benzoate microspheres and preparation method thereof

Examples

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Effect test

Embodiment 1

[0046] A preparation method of biodegradable emamectin benzoate microspheres, comprising the following steps:

[0047] (1) Preparation of drug-containing oil-phase suspension: mix 0.4710 g of emamectin benzoate technical compound with 0.6 g of polylactic acid, add 5 mL of dichloromethane and 5 mL of acetone, and dissolve in an ice-water bath. Obtain the oil phase suspension containing medicine;

[0048] (2) Preparation of primary emulsion: use a high-speed homogenizer to inject the drug-containing oil phase suspension in step (1) into 250 mL of polyvinyl alcohol and gelatin aqueous solution under the condition of uniform dispersion of milk, wherein polyethylene The mass ratio of alcohol to gelatin is 1:1, the content of polyvinyl alcohol and gelatin in the aqueous solution is 15 mg / ml, and an O / W primary emulsion is prepared; the emulsification conditions are: temperature 30°C, dispersion speed 8000 rpm, emulsification time 0.5 min;

[0049] (3) Preparation of microspheres: ...

Embodiment 2

[0053] A kind of preparation method of the biodegradable type emamectin benzoate microsphere that adds coating, comprises the following steps:

[0054] (1) Preparation of drug-containing oil-phase suspension: mix 1.1775 g of emamectin benzoate technical compound with 1.5 g of polylactic acid, add 5 mL of dichloromethane and 5 mL of acetone, and place in an ice-water bath Dissolved to obtain a drug-containing oil phase suspension;

[0055] (2) Preparation of primary emulsion: use a high-speed homogenizer to inject the drug-containing oil-phase suspension in step (1) into 100 mL of 20 mg / ml gelatin aqueous solution under the condition of homogeneous emulsion dispersion to prepare O / W primary emulsion; emulsification conditions: temperature 20°C, dispersion speed 6000 rpm, emulsification time 0.5min;

[0056] (3) Preparation of microspheres: Pour all the primary emulsion in step (2) into a large beaker with 200 mL of water placed on a magnetic stirrer, keep the reaction tempera...

Embodiment 3

[0060] A kind of preparation method of the biodegradable type emamectin benzoate microsphere that adds coating, comprises the following steps:

[0061] (1) Preparation of drug-containing oil-phase suspension: mix 0.6180 g of emamectin benzoate technical compound with 1.2 g of polylactic acid, add 5 mL of dichloromethane and 5 mL of ethyl acetate, and place in an ice-water bath Dissolved to obtain a drug-containing oil phase suspension;

[0062] (2) Preparation of primary emulsion: using a high-speed homogenizer, inject the drug-containing oil-phase suspension in step (1) into 200 mL of 10 mg / ml gelatin aqueous solution under the condition of homogeneous emulsion dispersion to prepare O / W primary emulsion; emulsification conditions: temperature 25°C, dispersion speed 10000 rpm, emulsification time 0.5min;

[0063] (3) Preparation of microspheres: Pour all the primary emulsion in step (2) into a large beaker with 200 mL of water placed on a magnetic stirrer, keep the reaction ...

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Abstract

The invention relates to encapsulated emamectin benzoate microspheres and a preparation method thereof. The preparation method of the present invention solves the problems of low encapsulation efficiency and drug surface crystallization in traditional methods for preparing emamectin benzoate microspheres, alleviates environment stress caused by traditional non-degradable wall materials such as polyureas, polyurethane, and the like, and solves the problem of overquick burst release easily seen in traditional pesticide microspheres. The encapsulated biodegradable emamectin benzoate microspheres of the invention is wide in control spectrum, high in drug effect, strong in stability, less in environment pollution, long in lasting period, and low in control cost, and meets the requirements for pollution-free agricultural production.

Description

technical field [0001] The invention belongs to the technical field of pesticides, and in particular relates to a coated biodegradable emamectin benzoate microsphere and a preparation method thereof. Background technique [0002] Emamectin benzoate (emamectin benzoate, referred to as emamectin for short) is an antibiotic insecticide and acaricide, which has excellent control effect on Lepidoptera pests. At present, the main dosage form of emamectin benzoate is still the traditional old dosage form such as emulsifiable concentrate, but the benzene organic solvent used in the processing of emulsifiable concentrate will cause serious pollution to the environment, and the There are great security risks. In addition, emamectin benzoate is easy to decompose when exposed to light, and the duration of effect is short, resulting in high frequency of medication, low control effect, and great impact on the environment; and long-term large-scale use is easy to induce target pests Gen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/10A01N25/28A01N43/90A01P7/02A01P7/04
Inventor 吴刚张少飞陈鹏浩张飞吴祖建
Owner FUJIAN AGRI & FORESTRY UNIV
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