Laser preparation method of porous bone scaffold and adding zinc oxide to improve performance

Abstract

The invention relates to a method for preparing a porous bone scaffold by laser and increasing mechanical and biological performances of the porous bone scaffold by adding zinc oxide with little amount, which belongs to the bone tissue engineering field. Aiming at uncontrollable performances of aperture distribution, shape, space direction and connectivity in the preparation method of a traditional bone scaffold, and aiming at the disadvantages of poor mechanical property and fast resolving rate existed in tricalcium phosphate (beta-TCP), the invention provides the method for preparing the porous bone scaffold by using a selective laser sintering (SLS) technology, and provides the method for increasing performance by adding zinc oxide (ZnO). The method for preparing the porous bone scaffold has the advantages that the porous scaffold which enables three-dimensional interconnection is prepared by SLS, zinc oxide with little amount is added for introducing into a liquid phase, the particles densification can be promoted, crystal grain is refined, and the mechanical performance is improved, simultaneously, cell compatibility is increased, the degradation rate is reduced, and the biological performance is increased, so that the interconnected porous beta-TCP bone scaffold with enhanced mechanical performance and good biological performance can be finally prepared. The method has the advantages of simple preparation technology, convenient operation, low cost, easy control of technical parameter and the like.

Description

technical field [0001] The invention relates to a three-dimensional interconnected porous bone scaffold prepared by selective laser sintering (SLS) technology, and by adding a small amount of zinc oxide (ZnO) to increase β-tricalcium phosphate (β-Ca 3 (PO 4 ) 2 , a method for the mechanical and biological properties of a β-TCP) scaffold, belonging to the field of bone tissue engineering. Background technique [0002] Tissue engineering is a discipline in which cells are planted on a three-dimensional scaffold with a certain spatial structure. Cells grow, proliferate, differentiate and build biological substitutes on the scaffold, and then transplanted to the tissue defect site to restore tissue function. Bone tissue engineering scaffolds not only provide support for the construction of tissue cells, but also provide a suitable external environment for cell growth, so as to facilitate the adhesion, proliferation and differentiation of bone cells. This requires the scaffold...

AI Technical Summary

Problems solved by technology

However, β-TCP has shortcomings such as high brittleness and low strength, which limit its use in the weight-bearing parts of the human body.

And the biodegradation rate is fast and difficult to control, which cannot match the rate of new tissue generation

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