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Traditional Chinese medicine (TCM) composition and preparation method and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its preparation and application, can solve the problems of complex prescriptions and high treatment costs, achieve the effects of alleviating pain, reducing attack frequency and intensity, and relieving neurasthenia

Inactive Publication Date: 2014-06-18
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are also traditional Chinese medicine compound prescriptions for treating migraine (vascular neuropathic headache), the prescriptions are generally complicated and the treatment costs are high

Method used

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  • Traditional Chinese medicine (TCM) composition and preparation method and application thereof
  • Traditional Chinese medicine (TCM) composition and preparation method and application thereof
  • Traditional Chinese medicine (TCM) composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, preparation Chinese medicine composition

[0031] 1. Weigh the following raw materials: Trillium 15g, Salvia miltiorrhiza 30g and Rhizoma Chuanxiong 10g.

[0032] 2. Add the above raw materials to 8 times the quality of water, soak for 30 minutes; then heat and decoct twice, each decoction time is 1 hour, filter, combine the filtrate, concentrate under reduced pressure to 55ml, each ml is equivalent to 1g of crude drug .

Embodiment 2

[0033] Example 2. Experimental study on the treatment of migraine with Zhudanzhitong formula (the traditional Chinese medicine composition prepared in Example 1)—pharmacodynamic study on nitroglycerin-type experimental migraine rats

[0034] The behavioral symptoms, pathological and biochemical changes of the nitroglycerin-type experimental migraine rat model are similar to those of human migraine attacks, and it is currently the most reported experimental migraine animal model. In this model, focus on observing the effect of drugs on improving headache symptoms and on nitric oxide and nitric oxide synthase, which are vasoactive substances.

[0035] 1. Preparation of animal models

[0036] References for the preparation of nitroglycerin-type experimental migraine rat model (Fu Xianjun. Evaluation of behavioral symptoms of nitroglycerin-type experimental migraine rat model[J]. Chinese Journal of Neurology, 2005, 4(5): 449 -451.; Zhang Zhengxiang. Validity evaluation of experim...

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Abstract

The invention discloses a traditional Chinese medicine (TCM) composition and a preparation method and application thereof. The TCM composition comprises the following active ingredients in parts by weight: 5 to 45 parts of trillium tschonoskii, 10 to 90 parts of salvia miltiorrhiza, and 3 to 30 parts of ligusticum wallichii. The preparation method of the TCM composition comprises the following steps of: mixing trillium tschonoskii, salvia miltiorrhiza, and ligusticum wallichii in parts by weight to obtain a mixture; adding water to the mixture for soaking; then decocting for two to three times, filtering, and combining filtrates to obtain the composition. The traditional pharmaceutical trillium tschonoskii of Tujia people has sedation and analgesia functions, salvia miltiorrhiza has efficacies of tranquilizing by nourishing the heart, and relieving restlessness by clearing the heart, and ligusticum wallichii has efficacies of promoting the circulation of qi by activating blood, and promoting the blood circulation of head and eyes. The number of medicines is few, the compatibility is rigorous, and the composition has efficacies of promoting blood circulation to remove meridian obstruction and ataralgesia. The TCM composition play an exact role in clinic treatment of migraine, can ease neurasthenia, restlessness, anxiety and other mental behavior symptoms, reduces migraine attack frequency and intensity, relieves the suffering of patients, and improves the quality of life of the patients.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, a preparation method and application thereof. Background technique [0002] Migraine, or claim angioneurotic headache, is a kind of clinical frequently-occurring disease and common disease. The disease is a recurrent paroxysmal headache caused by intracranial and extracranial blood vessels and neuromodulation disorders, including vascular headache and neuropathic headache. Owing to have the characteristic of vascular disease clinically, have the clinical manifestation of neuropathic headache again, are collectively referred to as angioneurotic headache. Angioneurotic headache has the characteristics of sudden onset, severe pain, recurrent attacks, lingering course, and long-term refractory. It is a common clinical disease and frequently-occurring disease. [0003] In recent years, migraine has been clinically classified as a psychosomatic disease. Studies have shown that sleep disor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P25/06A61P25/00A61P25/22
Inventor 邹海艳赵晖溪胜艳
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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