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Medicine composition for treating urocystitis

A composition, the technology of cystitis, applied in the field of treating cystitis

Active Publication Date: 2014-06-18
北京亿灵医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few of these treatments produce sustained relief

Method used

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  • Medicine composition for treating urocystitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Preparation of collagen perfusate

[0022] Prescription specifications: 50ml: 5g, concentration 10%

[0023] Collagen 100g Sodium chloride 8.5g Disodium phosphate 0.50g Sodium dihydrogen phosphate 0.04g Water for Injection Up to 1000ml (20 bottles)

[0024] Preparation: Make liquid under nitrogen-filled conditions, measure 90% volume of water for injection in the liquid mixing tank, weigh the prescription amount of sodium chloride, disodium hydrogen phosphate, and sodium dihydrogen phosphate, add it to the water, stir for 15 minutes to complete the dissolution Finally, add collagen, stir for 15 minutes to complete the dissolution, add water to the full volume, add 0.05% (w / v total volume) of activated carbon, absorb at 40-60°C for 15 minutes, decarbonize, and pass through a 0.22 μm filter membrane. Determination of intermediates, 95.0% of the labeled amount, so that the pH value is within the range of 7.2±0.1, filled ...

Embodiment 2

[0025] Example 2 Preparation of collagen perfusate

[0026] Prescription specifications: 50ml: 4g, concentration 8%

[0027] Collagen 80g Sodium chloride 8.5g Disodium phosphate 0.778g Sodium dihydrogen phosphate 0.06 Water for Injection Up to 1000ml (20 bottles)

[0028] Preparation: Make liquid under nitrogen-filled conditions, measure 90% volume of water for injection in the liquid mixing tank, weigh the prescription amount of sodium chloride, disodium hydrogen phosphate, and sodium dihydrogen phosphate, add it to the water, stir for 15 minutes to complete the dissolution Finally, add collagen, stir for 15 minutes to complete the dissolution, add water to the full volume, add 0.05% (w / v total volume) of activated carbon, absorb at 40-60°C for 15 minutes, decarbonize, and pass through a 0.22 μm filter membrane. Determination of intermediates is 105.0% of the labeled amount, so that the pH value is within the range of 7.2±0.1, filled...

Embodiment 3

[0029] Example 3 Preparation of collagen perfusate

[0030] Prescription specifications: 50ml: 3.5g, concentration 7%

[0031] Collagen 70g Sodium chloride 8.5g Disodium phosphate 0.50g Sodium dihydrogen phosphate 0.04g water for injection to 1000ml (20 bottles)

[0032] Preparation: Make liquid under nitrogen-filled conditions, measure 90% volume of water for injection in the liquid mixing tank, weigh the prescription amount of sodium chloride, disodium hydrogen phosphate, and sodium dihydrogen phosphate, add it to the water, stir for 15 minutes to complete the dissolution Finally, add collagen, stir for 15 minutes to complete the dissolution, add water to the full volume, add 0.05% (w / v total volume) of activated carbon, absorb at 40-60°C for 15 minutes, decarbonize, and pass through a 0.22 μm filter membrane. Determination of intermediates, 104.1% of the labeled amount, so that the pH value is within the range of 7.2±0.1, nitrogen ...

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Abstract

The invention relates to a medicine composition for treating urocystitis. The medicine composition is characterized by consisting of collagen and a water carrier. The collagen composition solution disclosed by the invention is given in a perfusion manner, therefore, the medicine directionally reaches the surface of the infected cavity (mucosa) of the urinary bladder or patients suffering urocystitis, especially interstitial cystitis, can be used for treating related urinary bladders and is applicable to patents whose lining of the urinary bladder or urethra or lining of the ureter is corroded.

Description

technical field [0001] The present invention relates to therapeutic agents and methods for treating cystitis, including interstitial cystitis and related bladder disorders. Background technique [0002] Interstitial cystitis (interstitial cystitis, IC), also known as bladder submucosal fibrosis or Hunner's ulcer, is a multifactorial syndrome characterized by bladder fibrosis, pain in the suprapubic region during the storage period, and urinary frequency, urgency, or nocturnal Symptoms such as increased urination. At present, the pathogenesis is still unclear, and the treatment is based on clinical experience and symptomatic treatment. At present, bladder infusion is mostly used to treat interstitial cystitis clinically, and the methods used are various with different effects. [0003] Sant and La Rock pointed out in Interstitial Cystitis, Vol.21 (1) that existing treatments include drug therapy, and intravesical use of dimethyl sulfoxide is the only FDA-approved therapy. H...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K9/00A61P13/10A61P13/02A61K31/737A61K31/728
Inventor 关屹闫冬高晓峰
Owner 北京亿灵医药科技发展有限公司
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