Oral matrix film and preparation method thereof

一种基质膜、口腔的技术，应用在口腔基质膜及其制备领域，能够解决不能确保植骨治疗获得成功、缺乏可生物降解等问题，达到设备成本低廉、组织附着性好、促进细胞繁殖的效果

Active Publication Date: 2016-09-14
GUANGZHOU HONGJIAN BIOMEDICAL PROD TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the lack of biodegradable matrix materials in the existing periodontal disease treatment technology, and can not ensure the success of bone grafting treatment. Provided is an oral matrix membrane that has good tissue adhesion, can promote cell proliferation, and can completely biodegrade within a certain period of time, and a preparation method thereof

Method used

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  • Oral matrix film and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] The base material of the oral matrix film in this example is made of polylactic acid polymer (PDLLA), acetyl tributyl citrate (ATBC) and L-polylactic acid (PLLA), in which polylactic acid polymer is 77%, acetyl citric acid 13% for tributyl ester and 10% for L-polylactic acid.

[0023] The molecular weight of polylactic acid polymer is 200,000, and the molecular weight of L-polylactic acid is 50,000 to 80,000. The molecular weight of PDLLA is about 200,000, which is conducive to processing and molding. The function of adding PLLA is to enhance the physical strength of the film. The degradation time of PLLA is slower than that of PDLLA, so its molecular weight is lower, which is helpful for degradation. The intrinsic viscosity of the final oral matrix film substrate is >1.0 dl / g.

[0024] The oral matrix membrane has a three-layer structure, namely an upper layer 1 , a middle layer 2 and a bottom layer 3 , and each layer is provided with a through hole 4 .

[0025] The ...

Embodiment 2

[0028] The oral matrix film of this example is the same as Example 1 except that the proportion of the base material components is 89.5% of polylactic acid polymer, 10.5% of acetyl tributyl citrate, and 0 of L-polylactic acid.

Embodiment 3

[0030] The oral matrix film of this example is the same as Example 1 except that the proportion of the base material is 75% of polylactic acid polymer, 13% of acetyl tributyl citrate, and 12% of L-polylactic acid.

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Abstract

The invention belongs to an oral matrix membrane and a preparation method thereof in the field of preparation methods of medical biodegradable filling materials. The base material of the oral matrix membrane is composed of polylactic acid polymer (PDLLA), acetyl tributyl citrate (ATBC) and Polylactic acid (PLLA) is mixed, of which polylactic acid polymer is 75~89.5%, acetyl tributyl citrate is 10.5~13%, and L-polylactic acid is 0~12%. The oral matrix membrane has a three-layer structure, that is, an upper layer (1), a middle layer (2) and a bottom layer (3), and each layer is provided with through holes (4). The invention overcomes the lack of biodegradable matrix materials in the existing periodontal disease treatment technology and cannot ensure the success of bone grafting treatment. The oral matrix membrane and its preparation method provided for people have good tissue adhesion and can promote cell Reproduction, and can be completely biodegradable within a certain period of time.

Description

Technical field: [0001] The invention belongs to the field of preparation methods of medical biodegradable filling materials, and in particular relates to an oral matrix membrane and a preparation method thereof. Background technique: [0002] Human alveolar bone is the most active bone tissue in the human body, and it tends to absorb throughout life. Once absorbed, the current technology cannot reverse its hyperplasia. Teeth are rooted in the alveolar bone, and the natural resorption of the alveolar bone is the main cause of senile tooth loss and loss of masticatory function. In addition, the destruction of alveolar bone caused by periodontal disease, because there is currently no technical method to promote alveolar bone hyperplasia, in addition to controlling the inflammation of periodontal disease, the only way to allow the alveolar bone to be destroyed is to cause all teeth to fall out. [0003] Although a variety of bone graft materials and bone graft methods have b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/26A61L27/50
Inventor 朱晓明
Owner GUANGZHOU HONGJIAN BIOMEDICAL PROD TECH CO LTD
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