Vaccine composition for mucosal administration

A vaccine composition and mucosal administration technology, applied in the directions of vaccines, drug combinations, drug delivery, etc., can solve the problems of giving difficult medical workers acupuncture accident patients, heat-labile enterotoxin, etc., and avoid acupuncture infection. Risk of accident, improvement of quality of life, effect of improved efficiency
CN103961697AInactive Publication Date: 2014-08-06NITTO DENKO CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NITTO DENKO CORP
Publication Date
2014-08-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a vaccine composition which comprises a cellular immunity induction promoter universally usable against various antigens in cellular immunity induction by mucosal administration of the antigen and exerts a high cellular immunity inducing effect by mucosal administration. The present invention provides a vaccine composition for mucosal administration to induce cellular immunity, comprising: (i) an antigen; and (ii) one or more cellular immunity induction promoters selected from the group consisting of a TLR ligand, a cyclic dinucleotide, a helper peptide and an immunomodulatory small molecule drug.
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Description

technical field

[0001] The present invention relates to vaccine compositions for mucosal administration. Background technique

[0002] Vaccines that are widely used generally administer pathogens such as microorganisms or viruses or parts thereof in order to induce immunity. In addition, there are cancer vaccines, the purpose of which is to enable the cellular immune system to recognize cancer cell-specific antigens, thereby inducing a specific attack on cancer cells through the immune system, which is used as one of the means of cancer treatment.

[0003] Usually, the invasion of microorganisms, viruses, due to their size, is prevented by the skin, therefore, vaccines need to be administered invasively into the body. Thus, immunization usually uses injections. However, injections have the following problems: pain, fear, injection scars and scars developed from injection scars, only medical workers can perform injections, intradermal injections with high immune effects are...

Claims

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