Rapid detection method of Chuanxiong medicinal materials
A detection method and technology of Chuanxiong, which is applied in the field of rapid detection of Chuanxiong medicinal materials, can solve the problems of poor specificity, large variation of medicinal material content, and many constraints on promotion and application, and achieve the effect of effective detection and good reproducibility.
Inactive Publication Date: 2016-10-26
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology
The content of ligustilide in the crude drug is about 0.6%, accounting for about 58% of the total volatile oil. The content of this component is of certain significance for distinguishing whether it is from the authentic area, but ligustilide can undergo dehydrogenation and oxidation at room temperature , hydrolysis, degradation and other isomerization reactions, the content of medicinal materials changes greatly during storage, and its stability is a concern when it is used as a quality control index; the content of ferulic acid in crude drugs is about 0.1% to 0.2%, However, ferulic acid is a common component of many medicinal plants, and its specificity is poor as a quantitative indicator; while the content of ligustrazine in crude drugs is less than 1 / 10,000, it is not suitable as an index component for quality control of medicinal materials
The use of fingerprints in the quality control of Rhizoma Chuanxiong has also been reported, but its popularization and application is limited due to many restrictive factors
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Embodiment 1
[0022] The detection method of embodiment 1 Rhizoma Chuanxiong of the present invention
[0023] The intensity of fluorescence is closely related to the content of active ingredients such as ligustilide contained in Rhizoma Chuanxiong. If the fluorescence intensity in solid samples can be directly measured, a correlation calculation model between fluorescence intensity in solid samples and internal ligustilide and other active ingredients can be established. , which is expected to provide a basis for the establishment of a rapid and non-destructive quality evaluation method for Chuanxiong. Therefore, this study used fluorescence spectrophotometry to conduct a preliminary study on the measurement method of fluorescence intensity in Rhizoma Chuanxiong solid powder samples, and the results are as follows:
[0024] (1) Selection of filler type and dosage
[0025] During the pre-test, it was found that the solid sample powder box of the fluorescence spectrophotometer needs about 0...
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The invention provides a fast detection method for a Szechuan lovage rhizome medical material. The detection method adopts fluorescence spectrophotometry for detection and comprises the operating steps as follows: (1), Szechuan lovage rhizome is taken, smashed and uniformly mixed with a filling agent to obtain a solid powder sample; (2), ligustilide is taken as a reference substance; and (3), the solid powder sample and the reference substance are taken respectively and detected with the fluorescence spectrophotometry. The conditions of the fluorescence spectrophotometry are as follows: the excitation wavelength ranges from 320 nm to 325 nm, and the emission wavelength ranges from 452 nm to 458 nm. The detection method provided by the invention is good in reproducibility, can rapidly and effectively detect the quality of Szechuan lovage rhizome and provides guarantee for controlling quality of the authentic Szechuan lovage rhizome medical material.
Description
technical field [0001] The invention relates to a rapid detection method for Chuanxiong medicinal materials. Background technique [0002] Chuanxiong, formerly known as Xiongxiong. A traditional Chinese medicine plant, commonly used for promoting blood circulation, dispelling wind and relieving pain, mainly cultivated in Sichuan, Yunnan, Guizhou, Guangxi, Hubei and other places. Ligusticum chuanxiong is pungent, warm, fragrant and dry. When walking but not guarding, it can not only dissipate, but go up to reach the top; enter the blood, go down to reach the sea of blood. It has a wide range of functions of promoting blood circulation and removing blood stasis, suitable for stagnation of various diseases; dispelling wind and relieving pain, has very good effects, and can cure head wind, headache, rheumatic arthralgia and other diseases. The ancients said that Chuanxiong is the qi medicine in the blood, and it is almost said that it has the functions of dispersing pungent,...
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IPC IPC(8): G01N21/64
Inventor 彭成刘友平陈林陈鸿平
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE