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Method for continuously synthesizing N-carbamylglutamic acid by using micro-channel reactor

A technology of microchannel reactor and carbamoylglutamic acid, which is applied in chemical instruments and methods, preparation of organic compounds, preparation of urea derivatives, etc., can solve problems such as slow reaction speed, many by-products, complicated process, etc. Achieve the effect of rapid reaction, less by-products and less side reactions

Inactive Publication Date: 2014-08-13
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a method for continuously synthesizing N-carbamylglutamic acid in a microchannel reactor, so as to overcome the disadvantages of traditional synthesis methods such as slow reaction speed, many by-products, high cost, and complicated process

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  • Method for continuously synthesizing N-carbamylglutamic acid by using micro-channel reactor
  • Method for continuously synthesizing N-carbamylglutamic acid by using micro-channel reactor
  • Method for continuously synthesizing N-carbamylglutamic acid by using micro-channel reactor

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Embodiment 1～20

[0027] Prepare sodium glutamate and urea into aqueous solutions, respectively, with concentrations of C1 and C2; pump the sodium glutamate solution and urea solution into the microchannel reactor according to the volume flow ratio V1:V2, and pass through the microchannel reactor in turn. Reactor I and reactor II connected in series, total residence time in reactor I and reactor II is t, and temperature of reaction is T1 and T2 respectively; Recrystallization, etc.) to obtain N-carbamoylglutamic acid finished product.

[0028] The specific conditions and results of the EHRFELD slit-plate mixer reactor are shown in Table 1. The Vapourtec R4 / R2+ reactor only needs to halve both V1 and V2, and the other conditions are the same as in Table 1. The reaction effect is almost the same as that of the EHRFELD slit-plate mixer reactor.

[0029] Table 1

[0030]

[0031] (1) As can be seen from Examples 1 to 5, when the sodium glutamate solution concentration is 500 to 700g / L, and the ...

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Abstract

The invention discloses a method for continuously synthesizing N-carbamylglutamic acid by using a micro-channel reactor. The method comprises the following steps: (1) preparing a sodium glutamate solution and a urea solution, wherein the concentration of the sodium glutamate solution is 200-700g / L, and the concentration of the urea solution is 300-1000g / L; (2) respectively pumping the sodium glutamate solution and the urea solution into the micro-channel reactor at a volume flow ratio of 1 to (0.2-2.0), passing through a reactor I and a reactor II which are connected in series inside the micro-channel reactor, wherein the total retaining time inside the reactor I and the reactor II is 10-95 minutes, the temperature of the reactor I is 100-150 DEG C, and the temperature of the reactor II is 100-150 DEG C; (3) salting out and refining a material discharged from the micro-channel reactor, so as to obtain a finished product, namely, the N-carbamylglutamic acid. The method is rapid in reaction, high in mixing efficiency, high in conversion rate, less in amount of byproducts, low in cost and applicable to industrial production and application.

Description

technical field [0001] The invention relates to a method for continuously synthesizing N-carbamylglutamic acid in a microchannel reactor, belonging to the field of chemical synthesis and technology. Background technique [0002] Arginine is an essential amino acid for suckling piglets, and the amount of endogenous arginine synthesized by piglets is limited. Only breast milk supply and endogenously synthesized arginine cannot fully meet the optimal growth needs of piglets, so how to meet The arginine requirement of suckling piglets is particularly important. However, arginine is expensive, and directly adding arginine to the feed greatly increases the feed cost, so it is imperative to open up another way to increase the supply of arginine to piglets. [0003] The analogue of N-acetylglutamic acid, N-carbamylglutamic acid can activate carbamoyl phosphate synthase-I and dihydropyrrole-5-carboxylic acid synthase in animals, and promote the production of endogenous arginine in a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C275/16C07C273/18
Inventor 曹飞周佳栋汤智群周华崔莉燕郭凯
Owner NANJING UNIV OF TECH
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