Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Primers, kit and system for cancer diagnosis

A technology for malignant tumors and tumors, applied in the field of malignant tumors, can solve the problems of low diagnostic accuracy of malignant tumors and human injury to patients, and achieve convenient and accurate diagnosis

Inactive Publication Date: 2014-08-27
张灏
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the defects in the prior art that the diagnosis of malignant tumors is either not very accurate or requires physical injury to the patient in order to obtain the sample material of the tumor tissue, a primer and a kit for the diagnosis of malignant tumors can be provided conveniently and accurately and system

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Primers, kit and system for cancer diagnosis
  • Primers, kit and system for cancer diagnosis
  • Primers, kit and system for cancer diagnosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] Our study demonstrates that PTPRO gene expression is gradually "silenced" by the methylation process. Methylation, which adds methyl groups to a gene, reduces the activity of the methylated gene and reduces the levels of the protein it encodes. Therefore, when the PTPRO gene is silenced, the level of PTPRO enzyme will decrease accordingly, which will affect the protein regulated by PTPRO, and then lead to the occurrence of cancer.

[0018] Our study found that 75% of the primary tumor samples could detect PTPRO gene hypermethylation, and it was related to the depth of tumor invasion. Moreover, the hypermethylation of the PTPRO gene in the peripheral blood samples of breast cancer patients only existed in cases of the same hypermethylation in tumor tissues. This indicates that PTPRO gene can be used as a non-invasive molecular marker for breast cancer and solid tumors. Detecting the expression of PTPRO protein in peripheral blood can be used as an important indicator a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to primers, a kit and a system for cancer diagnosis. The primers for cancer diagnosis are PTPRO methylation specific primers. The PTPRO methylation specific primers comprise a first methylation specific primer having a sequence of 5'-GGTACGTTTTTGGAGGATTTC-3' and a second methylation specific primer having a sequence of 5'-ACGACTACGCTAACGAACTCC-3'. Through detection of a peripheral blood PTPRO gene methylation level, the primers, the kit and the system for cancer diagnosis can realize simple, convenient and accurate diagnosis of cancers.

Description

technical field [0001] The present invention relates to the field of malignant tumors, and more specifically relates to a primer, a kit and a system for diagnosing malignant tumors. Background technique [0002] Breast cancer is a malignant tumor that occurs in the glandular epithelial tissue of the breast. The global incidence of breast cancer has been on the rise since the late 1970s. Breast cancer has become a major public health problem in the current society. The etiology of breast cancer is not yet fully understood. Studies have found that there is a certain regularity in the incidence of breast cancer, and women with high-risk factors for breast cancer are prone to breast cancer. The so-called high-risk factors refer to various risk factors related to the onset of breast cancer, and the risk factors that most breast cancer patients have are called high-risk factors for breast cancer. [0003] The current diagnosis methods of breast cancer include imaging examinatio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6886C12Q2600/154
Inventor 张灏
Owner 张灏
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com