Preparation method of bone repair toothpaste agent inducing gene expression

A toothpaste paste and gene expression technology, applied in the field of bioactive toothpaste, can solve the problem of unable to repair damaged teeth and other problems

Active Publication Date: 2014-09-03
北京幸福益生高新技术有限公司
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  • Abstract
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Problems solved by technology

[0006] The third category: pharmaceutical toothpaste, for different conditions such as periodontitis; simple hem...

Method used

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  • Preparation method of bone repair toothpaste agent inducing gene expression
  • Preparation method of bone repair toothpaste agent inducing gene expression
  • Preparation method of bone repair toothpaste agent inducing gene expression

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preparation example Construction

[0022] The preparation method of toothpaste paste of the present invention comprises the steps:

[0023] (1) Generate biologically active hydroxyapatite: take CaO and P with specifications of 10-20nm 2 o 5 Nano-powder, mass ratio 1:1.67, mixed evenly into 500g of powder, aged at 36-38°C for at least 12 hours under dark conditions; add 500g of medical purified water and stir to form a paste, then add Na 2 o 2 (3g) stirred at 38°C for 45 minutes, and passed through a 10-20 mesh sieve to obtain hydroxyapatite Ca with a particle size of 10-20nm 10 (PO 4 ) 6 (OH) 2 (HA);

[0024] (2) Add SiO to the hydroxyapatite obtained in step (1) 2 (5g) After mixing evenly, lyophilize into powder at -15~-20°C, and add 10g of medical glycerin, 10g of medical polyethylene glycol, 3g of medical grade titanium dioxide, 1g of essence, carbomer 2- 3g, AK sugar 3g and sodium lauryl sulfate 2g, mix evenly;

[0025] (3) Sterilization: the paste obtained by mixing step (2) was irradiated and ste...

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Abstract

The invention relates to a preparation method of a bone repair toothpaste agent inducing gene expression. The main effect of the hydroxyapatite with the biological activity prepared by the method is a good effect to gingivitis, odonthemodia, dental calculus, bad breath, yellow teeth and teeth stains, dental ulcer, gomphiasis and tooth decay and particularly a remarkable effect to bad breath and odontorrhagia caused by odonthemodia and the oral cavity within 2-3 days, and a remarkable effect to looseness of teeth, teeth stains, dental calculus and tooth decay within 3-15 days. Compared with common toothpastes, the toothpaste has the biological repairing capacity, has the effect of inducing gene expression and has a three-dimensional reticular porous biological structure.

Description

technical field [0001] The invention relates to a toothpaste for bone restoration with inducible gene expression, in particular to a bioactive toothpaste which can prevent dental caries, loose teeth, bleeding gums, tooth restoration and the like for long-term continuous use. Background technique [0002] In today's toothpaste market in China, my country produces about 8 billion standard sticks of toothpaste (65 gram packages) each year, realizing a total output value of 14 billion yuan. The market capacity of toothpaste in my country should be between 22 billion and 24 billion yuan, and nearly 1 / 3 of the functional toothpaste market has not been developed. [0003] There are four types of toothpaste: [0004] The first category: desensitizing toothpaste, for people with sensitive teeth; [0005] The second category: caries prevention, children face acidic diet environment, damage to tooth decay. [0006] The third category: pharmaceutical toothpaste, for different conditi...

Claims

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Application Information

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IPC IPC(8): A61K8/86A61K8/25A61K8/24A61Q11/00A61P1/02
Inventor 胡方
Owner 北京幸福益生高新技术有限公司
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