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Mouthwash as well as preparation method and application thereof

A mouthwash and solution technology, which is applied in blood diseases, oral care, pharmaceutical formulations, etc., can solve problems such as failure-prone function and singleness, and achieve the effect of enhancing sterilization effect, improving taste, and mild taste.

Active Publication Date: 2021-07-09
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of easy failure and single function of chlorine dioxide mouthwash in the prior art, the present invention provides a mouthwash and its preparation method and application

Method used

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  • Mouthwash as well as preparation method and application thereof
  • Mouthwash as well as preparation method and application thereof
  • Mouthwash as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]The present embodiment provides a mouthwash, and every 1 mL of the mouthwash contains the following raw material components: 25 mg of chlorine dioxide solution, 0.1 mg of N-succinyl chitosan, 0.05 mg of sodium ammonium phytate, peppermint Amide 0.4mg, Flavor 0.25mg, Litsea cubeba essential oil 0.2mg, Sodium perfluorononenyloxybenzenesulfonate 7.5mg, Chitosan 0.04mg, Magnesium silicate 0.05mg, Polyaspartic acid 10mg and lemon Zinc acid 15mg, the solvent is deionized water.

[0039] Wherein, the flavoring agent is steviol glycoside and aspartame with a mass ratio of 1:1,

[0040] The mass percent of chlorine dioxide in the chlorine dioxide solution is 1.6%, and its preparation method is: reacting sodium chlorite and a sulfuric acid solution with a volume percent concentration of 10% to generate chlorine dioxide gas and pass through saturated sulfite After the sodium chlorate solution removes impurities, it is obtained by absorbing an aqueous solution containing 1.5g / mL po...

Embodiment 2

[0044] The present embodiment provides a mouthwash, and every 1 mL of the mouthwash contains the following raw material components: 20 mg of chlorine dioxide solution, 0.12 mg of N-succinyl chitosan, 0.07 mg of sodium ammonium phytate, peppermint Amide 6.0mg, Flavor 0.2mg, Litsea cubeba essential oil 0.05mg, Sodium perfluorononenyloxybenzenesulfonate 15mg, Chitosan 0.02mg, Magnesium silicate 0.06mg, Polyaspartic acid 5mg and Citric acid Zinc 60mg, the solvent is deionized water.

[0045] Wherein, the flavoring agent is steviol glycoside and aspartame with a mass ratio of 1.2:1,

[0046] The mass percentage of chlorine dioxide in the chlorine dioxide solution is 1.8%. After the sodium chlorate solution removes impurities, it is obtained by absorbing an aqueous solution containing 1.2 g / mL potassium carbonate and 50% (v / v) hydrogen peroxide.

[0047] The preparation method of above-mentioned mouthwash solution comprises the steps:

[0048] Weigh each component according to th...

Embodiment 3

[0050] The present embodiment provides a kind of mouthwash, and every 1mL described mouthwash contains the raw material components of following quality: chlorine dioxide solution 40mg, N-succinyl chitosan 0.08mg, sodium ammonium phytate 0.04mg, mint Amide 0.2mg, Flavoring Agent 6.0mg, Litsea Cubeba Essential Oil 0.6mg, Sodium Perfluorononenyloxybenzenesulfonate 5mg, Chitosan 0.05mg, Magnesium Silicate 0.03mg, Polyaspartic Acid 25mg and Citric Acid Zinc 10mg, the solvent is deionized water.

[0051] Wherein, the flavoring agent is steviol glycoside and aspartame with a mass ratio of 0.8:1,

[0052] The mass percentage of chlorine dioxide in the chlorine dioxide solution is 1.5%, and its preparation method is: reacting sodium chlorite and a sulfuric acid solution with a volume percentage concentration of 10% to generate chlorine dioxide gas and pass through saturated sulfite After the sodium chlorate solution removes impurities, it is obtained by absorbing an aqueous solution c...

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Abstract

The invention relates to the technical field of oral care products, and particularly discloses mouthwash as well as a preparation method and application thereof. Each 1 mL of the mouthwash comprises the following raw material parts by mass: 20 to 40 mg of a chlorine dioxide solution, 0.08 to 0.12 mg of N-succinyl chitosan, 0.04 to 0.07 mg of sodium phytate, 0.2 to 6.0 mg of a freshener, 0.2 to 6.0 mg of a flavoring agent, 0.05 to 0.6 mg of litsea cubeba essential oil, 5 to 15 mg of perfluorononenoxy sodium benzenesulfonate, 0.02 to 0.05 mg of chitosan, 0.03 to 0.06 mg of a stabilizer, 5 to 25 mg of a dispersant, 10 to 60 mg of a nutritional agent and a solvent of deionized water. The mouthwash provided by the invention is high in stability, has obvious effects of sterilizing, stopping bleeding, whitening teeth, removing tooth stains and preventing and treating oral ulcers, is less in irritation to oral mucosa, has no adverse reaction, and has a relatively high popularization value.

Description

technical field [0001] The invention relates to the technical field of oral care products, in particular to a mouthwash and its preparation method and application. Background technique [0002] With the development of economy and society and the improvement of people's living standards, people's dietary structure is also changing, and various oral problems corresponding to it are becoming more and more common. A series of complications caused by oral problems, such as oral mucosal ulcers, gingivitis, periodontitis, angular cheilitis, etc., affect people's normal life and work. And with the aggravation of the aging trend of my country's population, the number of oral diseases in the elderly group has also increased significantly compared with the past. In the survey of oral problems in the elderly, it was found that the prevalence of periodontal disease can be as high as 64.78%, and the prevalence of gum disease The rate is as high as 69.37%. According to the survey on the o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/46A61K8/55A61K8/73A61K8/20A61Q11/00A61P1/02A61P29/00A61P7/04A61K8/42A61K8/60A61K8/44
CPCA61K8/922A61K8/736A61K8/20A61K8/55A61K8/466A61K8/42A61K8/602A61K8/442A61Q11/00A61P1/02A61P29/00A61P7/04A61K2800/592Y02A50/30
Inventor 张灿翟朋达陈家昊孙雪莹王少卿谭博菲袁晓芊欧阳邵立吴海霞
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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