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Purpose of asphonin in preparation of medicine for treating Parkinson's disease

A technology for Parkinson's disease and Zhimu Ning, which is applied in the field of medicine, can solve the problems of expanding the side effects of drugs, enhancing the efficacy, and being expensive, so as to enhance the ability of scavenging free radicals, reduce the level of lipid peroxidation, and improve the distribution and morphology. Effect

Inactive Publication Date: 2014-09-03
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Most drugs in dopamine agonists are expensive, with large individual differences, and are prone to side effects such as orthostatic hypotension, nausea and vomiting, constipation, headache, and drowsiness
Drugs that inhibit dopamine metabolism are generally used in combination with other drugs, which not only enhances the efficacy of the drug, but also amplifies the side effects of the drug, etc.

Method used

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  • Purpose of asphonin in preparation of medicine for treating Parkinson's disease
  • Purpose of asphonin in preparation of medicine for treating Parkinson's disease
  • Purpose of asphonin in preparation of medicine for treating Parkinson's disease

Examples

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Embodiment 1

[0020] Establishment and grouping of animal models:

[0021] Male C57BL / 6 mice weighing 20-25g, 8-10 weeks old, were randomly divided into control group, MPTP model group, positive drug group, Zhimonin low, medium and high dose groups, 18 in each group. Placed at 23±2°C, the lighting time is 12h / day, and the animals are given drugs after one week of adaptation to the environment. Except the control group, the other groups were intraperitoneally injected with MPTP (30mg / kg) once a day, 30min later the positive drug group was injected with selegiline (10mg / kg), and the Zhimoning administration group was injected with Zhimoning (10mg / kg). , 20mg / kg, 40mg / kg), the model group was given an equal volume of normal saline, and administered again at an interval of 12h for 7 days. The control group was given normal saline throughout the course. Then, the behavior of the rats was first scored by openfield and catwalk methods, and then the changes of dopaminergic neurons in the substant...

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to purpose of flavonoid asphonin in preparation of medicines for treating Parkinson's disease. The invention establishes a Parkinson's disease animal and cell models, and comprehensively utilizes various behavioral, immunological, biochemical indicator research methods; and experiments confirm that the medicine can significantly improve dyskinesia symptoms of mice in the Parkinson's disease model, improve levels of striatal dopamine and its metabolites and reduce the dopaminergic neuron degeneration of compact part of substantia nigra; and it is found that the protective effects are correlative to antioxidant activity in scavenging free radicals and reduction of oxidative stress effect. Asphonin is rich in raw material sources, and has significant efficacy and multiple effect targets, so asphonin has certain development value and prospects in clinical application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of flavonoid compound Zhimoning in the preparation of medicines for treating Parkinson's disease. Background technique [0002] Parkinson's disease (PD) was first proposed and published by James Parkinson in 1817. It is a common degenerative disease of the central nervous system, often accompanied by movement disorder symptoms such as slow movement, muscle stiffness, resting tremor, and postural instability. . The main pathological features are degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and loss of striatal dopamine fibers. The pathogenesis of Parkinson's disease is complex, involving mitochondrial dysfunction, environmental toxins, oxidative stress, and excitotoxicity. In addition to these clinically significant movement disorders and pathological changes, there are some other neurological dysfunction, such as sleep d...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/16
Inventor 蒋杰张志坚冯国帅鲍青青李沙
Owner JINAN UNIVERSITY
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