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A kind of bile acid composition and preparation method thereof

A bile acid and composition technology, applied in the field of bile acid composition and its preparation, can solve the problems of farmers' economic loss, large consumption of reagents, difficult industrialization, etc. mild effect

Active Publication Date: 2016-05-11
SHANDONG LONGCHANG ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the methods for preparing bile acids mainly include chemical synthesis and natural bile extraction. These two methods for extracting bile acids have complex operations, large consumption of reagents, high cost, low yield, and are difficult to apply. Shortcomings such as industrialization, the bile acid that the prepared bile acid contains is of a great variety (the bile acid has many kinds, as lithocholic acid, chenodeoxycholic acid, deoxycholic acid, hyodeoxycholic acid, hyodeoxycholic acid, ursodeoxycholic acid, etc.) There are many kinds of bile acids such as oxycholic acid), there are many impurities, and the purity is low. Certain types of bile acids may even have adverse effects on animal organisms, such as lithocholic acid, which is chenodeoxycholic acid that passes through bacteria in the intestines. The substances produced by metabolism are highly toxic and can cause various diseases of the liver and gallbladder system, causing serious economic losses to farmers

Method used

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  • A kind of bile acid composition and preparation method thereof
  • A kind of bile acid composition and preparation method thereof
  • A kind of bile acid composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The bile acid composition, its active ingredient composition comprises hyodeoxycholic acid, hyodeoxycholic acid and chenodeoxycholic acid, the weight percent of the sum of hyodeoxycholic acid and hyodeoxycholic acid is 80.0%, and chenodeoxycholic acid The percentage by weight of the weight percentage is 18.0%, and the rest is moisture and ash (the sum of the percentage by weight is calculated as 100%).

[0022] The preparation method of this bile acid composition adopts the following steps:

[0023] (1) Saponification: Add 500 kg of pig gall powder crushed through a 40-mesh sieve into the reactor, then add 5000 L of sodium hydroxide solution with a mass fraction of 10%, heat and stir, and start when the solution in the reactor is heated to 100°C Timing, continue heating and stirring to keep the boiling state for 12 hours, then cool the saponified liquid generated by the reaction until the solid-liquid layer is separated, and use a pipeline centrifugal pump to centrifuga...

Embodiment 2

[0030] The bile acid composition, its active ingredient composition comprises hyodeoxycholic acid, hyodeoxycholic acid and chenodeoxycholic acid, the weight percentage of the sum of hyodeoxycholic acid and hyodeoxycholic acid is 78.0%, and chenodeoxycholic acid The percentage by weight of the weight percentage is 20.0%, and the rest is moisture and ash (the sum of the percentage by weight is calculated as 100%).

[0031] The preparation method and consumption are the same as in Example 1.

Embodiment 3

[0033] The bile acid composition, its active ingredient composition comprises hyodeoxycholic acid, hyodeoxycholic acid and chenodeoxycholic acid, the weight percent of the sum of hyodeoxycholic acid and hyodeoxycholic acid is 79.0%, and chenodeoxycholic acid The percentage by weight of the weight percentage is 20.0%, and the rest is moisture and ash (the sum of the percentage by weight is calculated as 100%).

[0034] The preparation method and consumption are the same as in Example 1.

[0035] During the preparation of the bile acid composition, crude bile acid composition is obtained through crude extraction. In the crude product, there are many kinds of bile acid compositions and are complex. In order to make the effect of the bile acid composition in livestock and poultry more obvious, through two steps of purification and recrystallization, other bile acids in the crude product of the bile acid composition , such as lithocholic acid, deoxycholic acid, etc., are removed f...

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Abstract

The invention especially discloses a bile acid composition and a preparation method thereof. The bile acid composition has effective ingredients including hyocholic acid, hyodeoxycholic acid and chenodeoxycholic acid, wherein the sum of the weight percentages of hyocholic acid and hyodeoxycholic acid is not less than 78.0%, the weight percentage of chenodeoxycholic acid is not less than 18.0%, and the balance is water and ash. The bile acid composition and the preparation method thereof have the beneficial effects that: the preparation method has the advantages of simple operation and mild conditions, does not adopt harmful and toxic organic solvents in the preparation process, and can be easily applied in industrialized production; the prepared bile acid is high in yield and high in purity, is added into a feed for feeding broiler chickens, can significantly improve the growth performance and slaughter performance of the broiler chickens, is beneficial for the broiler chickens to utilize fat, reduces the use of broiler chicken own fat, thereby improving the growth performance and slaughter performance of the broiler chickens, solving the problems of fat digestion and absorption in the feed, and improving the broiler chicken carcass quality.

Description

(1) Technical field [0001] The invention particularly relates to a bile acid composition and a preparation method thereof. (2) Background technology [0002] With the continuous development of the feed industry and animal husbandry, the research on the level of animal nutrition has shifted from the balance of amino acids to the two major balances of amino acids and fatty acids, and the proportion of energy in feed costs is also increasing, thus promoting the energy feed industry. development of. Fat digestion is the premise of fat utilization, and emulsification is the first step of fat digestion, and its degree also determines the digestion and absorption rate of fat. In order to improve the utilization rate of fat, it has been found through continuous research that adding emulsifiers to feed can improve the digestion and absorption rate of fat to a certain extent, so feed emulsifiers came into being. In recent years, the price of energy feed raw materials, especially oil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00A23K20/10A23K50/75
Inventor 籍立民
Owner SHANDONG LONGCHANG ANIMAL HEALTH PROD
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