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A kind of method for preparing degradable drug-loaded coating stent

A drug-loaded coating and steel sheet technology, applied in coatings, pharmaceutical formulations, medical science, etc., can solve the problems of restenosis, inability to effectively prevent blood vessels, and ineffective reduction of vascular stents, so as to achieve uniform coating, The effect of capturing endothelial cells in vitro with strong ability and important clinical application value

Inactive Publication Date: 2015-11-18
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] The purpose of the present invention is to provide a method for preparing degradable drug-loaded coating stents in order to solve the problems that the existing clinical vascular stents cannot effectively reduce thrombus formation, and cannot effectively prevent the occurrence of vascular restenosis.

Method used

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  • A kind of method for preparing degradable drug-loaded coating stent
  • A kind of method for preparing degradable drug-loaded coating stent
  • A kind of method for preparing degradable drug-loaded coating stent

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Embodiment Construction

[0030] The method for preparing degradable drug-loaded coating stent provided by the present invention, its specific method is as follows:

[0031] The first step, pretreatment: first polish the steel sheet to a mirror surface with a polishing machine, then clean the polished steel sheet with decontamination powder, then ultrasonically clean it with acetone and ethanol, and finally ultrasonically clean it with deionized water; then prepare The freeze-dried product of the compound formed by the condensation of dopamine and heparin; the steel sheet and the freeze-dried product are sterilized by ultraviolet light; the configuration of tris buffer solution: Tris base 0.121 is dissolved in 80ml Milli-Q water, and the pH value is adjusted with 1M hydrochloric acid 8.5, set the volume to 100ml, verify the pH value, sterilize, and prepare heparin sodium solution: 100ml of Milli-Q aqueous solution of 3mg / ml heparin sodium, adjust the pH value to 4.2 with 0.1M NaOH and 1% acetic acid, an...

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Abstract

The invention provides a method for preparing a degradable drug-loaded coating stent. The method comprises the following specific steps: firstly, preprocessing, secondly, dissolving a freeze-dried material obtained in the first step in a trihydroxymethyl aminomethane buffer solution, thirdly, coating a steel sheet, fourthly, coating staphylococcus aureus A protein, and fifthly closing. The preparation method for preparing the degradable drug-loaded coating stent is used for solving lots of problems in the drug coating stents applied at present, and the drug coating prepared by use of the preparation method is resistant to scouring, even, stable, high in capability of capturing endothelial progenitor cells in vitro, and capable of achieving the purposes of well inhibiting thrombogenesis and reducing restenosis, and has important clinical application value.

Description

technical field [0001] The invention relates to a method for preparing a stent, in particular to a method for preparing a degradable drug-loaded coating stent. Background technique [0002] At present, cardiovascular disease has become one of the most important diseases threatening human life. According to the World Health Organization, about 17 million people die from cardiovascular diseases every year, accounting for one-third of the global death toll. It is estimated that by 2020, this number may exceed 20 million. 80% of cardiovascular disease deaths occur in low- and middle-income countries. A survey and analysis of the causes of death in my country shows that in recent years, cardiovascular and cerebrovascular diseases account for 40% of the deaths among Chinese people, and this proportion is getting younger and rising. Among cardiovascular diseases, myocardial infarction is the most serious disease to human beings, which has become the number one cause of death in o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/08A61K45/00A61K38/18A61K39/395A61K39/085A61L31/08A61L31/10A61L31/16
Inventor 宋春莉李倩刘斌刁鸿英赵丽艳张基昌于雲鹏史永峰王冠王金鹏
Owner JILIN UNIV
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