Traditional Chinese medicine for treating bronchiectasia caused by phlegm-heat obstructing lung and a preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine for treating bronchiectasia caused by phlegm-heat obstructing lung and a preparation method thereof. The traditional Chinese medicine comprises the following raw herbal materials: bulbus fritillariae cirrhosae, radix ophiopogonis, trichosanthes kirilowii maxim, scutellaria baicalensis, radices trichosanthis, arisaema cum bile, platycodon grandiflorum, concretio silicea bambusae, scaphium scaphigerum, concha meretricis seu cyclinae, fructus perillae, almond, aster, flos farfarae, folium mori, draba nemorosa, momordica grosvenori, thorny elaeagnus leaf, cortex lycii radicis, Chinese holly, calyx seu fructus physalis, Chinese olive, cordate houttuynia, sanicula lamelligera hance, adhatoda ventricosa, cudrania cochinchinensis, roughhaired holly root and ligularia rumicifolia. The traditional Chinese medicine has the beneficial effects that the traditional Chinese medicine has the efficacies of clearing heat and clearing the lung, and reducing phlegm and stopping coughing, is mainly used for treating bronchiectasia caused by phlegm-heat obstructing lung, is good in curative effect, short in treatment course, good in clinical treatment effect, small in toxic and side effects, simple in preparation process, easy to prepare, and low in cost, syndrome differentiation and treatment can be carried out from the whole body, the pharmacological effect is through to a focus of infection, and the drug tolerance is not easily generated.

Description

technical field

[0001] The invention relates to the technical field of pharmacy, in particular to a traditional Chinese medicine for treating phlegm-heat stagnant lung type bronchiectasis and a preparation method thereof.

[0002] Background technique

[0003] Bronchiectasis is due to chronic suppurative inflammation and fibrosis of the bronchi and its surrounding lung tissue, which destroys the muscle and elastic tissue of the bronchial wall, resulting in deformation and persistent dilation of the bronchi. Typical symptoms are chronic cough, expectoration of profuse purulent sputum, and recurrent hemoptysis. The main pathogenic factors are bronchial infection, obstruction and traction, and some have congenital genetic factors. Most patients have a history of measles, whooping cough or bronchopneumonia.

[0004] Etiology

[0005] 1. Infection

[0006] Infection is the most common cause of bronchiectasis. Tuberculosis, whooping cough, and adenovirus pneumonia can be...

Examples

preparation example Construction

[0080] Wherein, when the dosage form of the Chinese medicine is a spray, its preparation method comprises the following steps:

[0081] a. Weigh all raw medicinal materials according to the stated ratio, add water 3-5 times the weight of the obtained mixture and soak for 3-10 hours, after boiling with high fire, use slow fire to fry slowly for 30-50 minutes until the dosage of the medicinal liquid is 100-300ml, decoct 3 times, combine the decoction and filter, heat the filtrate to obtain extract 1, and use the dregs for later use;

[0082] b. Soak the dregs of step a with 60-90% ethanol for 0.5-1.5 hours, extract twice, each time for 1-2 hours, combine the extracts, filter, concentrate, filter with 80-160 mesh, 6000-10000 The supernatant after centrifugation at rpm is ultrafiltered through an ultrafiltration column with a cut-off molecular weight of 5000-10000, and the ultrafiltrate is concentrated under reduced pressure to obtain an extract 2 with a relative density of 1.35 a...

Embodiment 1

[0098] Embodiment 1 Spray of the present invention

[0099] Take 15g of Fritillaria, 27g of Ophiopogon japonicus, 23g of Trichosanthes baicalensis, 17g of Scutellaria baicalensis, 29g of trichosanthes, 40g of Dannanxing, 23g of bellflower, 13g of geranium, 30g of fat sea, 25g of sea clam shell, 28g of perilla seed, 5g of almond, and 12g of aster , Coltsfoot flower 20g, mulberry leaves 33g, Tinglizi 27g, Luo Han Guo 12g, cotyledon leaves 10g, Digupi 31g, g, Sijiqing 32g, brocade lantern 26g, green fruit 20g, Houttuynia cordata 30g, lung meridian 15g, Dabagu 27g, Chuanposhi 29g, Gangmeigen 31g and Tibetan Liwu 31g. .

[0100] Its preparation method comprises the following steps:

[0101] a. Weigh all the raw medicinal materials according to the stated ratio, add water 3 times the mass of the obtained mixture and soak for 10 hours, after boiling with strong fire, switch to slow fire for 30 minutes until the dosage of the medicinal liquid is 300ml, decoct 3 times , the combined...

Embodiment 2

[0105] Embodiment 2 lozenge of the present invention

[0106] Take Chuan Fritillaria 30g, Ophiopogon japonicus 23g, Trichosanthes 16g, Scutellaria baicalensis 25g, Trichosanthes 34g, Dannanxing 29g, Platycodon grandiflorum 16g, Tianzhuhuang 24g, fat sea 32g, sea clam shell 21g, perilla seed 18g, almond 8g, aster 14g , Coltsfoot flower 30g, mulberry leaves 24g, Tinglizi 29g, Luo Han Guo 19g, cotyledon leaves 17g, Digupi 23g, g, Sijiqing 23g, brocade lantern 36g, green fruit 13g, houttuynia cordata 36g, lung meridian grass 7g, Dabagu 16g, Chuanposhi 27g, Gangmeigen 21g and Tibetan Liwu 38g.

[0107] Its preparation method comprises the following steps:

[0108]In the first step, mix Fritillaria chinensis, Ophiopogon japonicus, Trichosanthes chinensis, Scutellaria baicalensis, Trichosanthes chinensis and Platycodon grandiflorum in the stated proportions, soak in ethanol with an alcohol concentration of 95% that is 6 times the mass of the obtained mixture, and heat to reflux for ...

technical field

[0001] The invention relates to the technical field of pharmacy, in particular to a traditional Chinese medicine for treating phlegm-heat stagnant lung type bronchiectasis and a preparation method thereof.

[0002] Background technique

[0003] Bronchiectasis is due to chronic suppurative inflammation and fibrosis of the bronchi and its surrounding lung tissue, which destroys the muscle and elastic tissue of the bronchial wall, resulting in deformation and persistent dilation of the bronchi. Typical symptoms are chronic cough, expectoration of profuse purulent sputum, and recurrent hemoptysis. The main pathogenic factors are bronchial infection, obstruction and traction, and some have congenital genetic factors. Most patients have a history of measles, whooping cough or bronchopneumonia.

[0004] Etiology

[0005] 1. Infection

[0006] Infection is the most common cause of bronchiectasis. Tuberculosis, whooping cough, and adenovirus pneumonia can be...

Examples

preparation example Construction

[0080] Wherein, when the dosage form of the Chinese medicine is a spray, its preparation method comprises the following steps:

[0081] a. Weigh all raw medicinal materials according to the stated ratio, add water 3-5 times the weight of the obtained mixture and soak for 3-10 hours, after boiling with high fire, use slow fire to fry slowly for 30-50 minutes until the dosage of the medicinal liquid is 100-300ml, decoct 3 times, combine the decoction and filter, heat the filtrate to obtain extract 1, and use the dregs for later use;

[0082] b. Soak the dregs of step a with 60-90% ethanol for 0.5-1.5 hours, extract twice, each time for 1-2 hours, combine the extracts, filter, concentrate, filter with 80-160 mesh, 6000-10000 The supernatant after centrifugation at rpm is ultrafiltered through an ultrafiltration column with a cut-off molecular weight of 5000-10000, and the ultrafiltrate is concentrated under reduced pressure to obtain an extract 2 with a relative density of 1.35 a...

Embodiment 1

[0098] Embodiment 1 Spray of the present invention

[0099] Take 15g of Fritillaria, 27g of Ophiopogon japonicus, 23g of Trichosanthes baicalensis, 17g of Scutellaria baicalensis, 29g of trichosanthes, 40g of Dannanxing, 23g of bellflower, 13g of geranium, 30g of fat sea, 25g of sea clam shell, 28g of perilla seed, 5g of almond, and 12g of aster , Coltsfoot flower 20g, mulberry leaves 33g, Tinglizi 27g, Luo Han Guo 12g, cotyledon leaves 10g, Digupi 31g, g, Sijiqing 32g, brocade lantern 26g, green fruit 20g, Houttuynia cordata 30g, lung meridian 15g, Dabagu 27g, Chuanposhi 29g, Gangmeigen 31g and Tibetan Liwu 31g. .

[0100] Its preparation method comprises the following steps:

[0101] a. Weigh all the raw medicinal materials according to the stated ratio, add water 3 times the mass of the obtained mixture and soak for 10 hours, after boiling with strong fire, switch to slow fire for 30 minutes until the dosage of the medicinal liquid is 300ml, decoct 3 times , the combined...

Embodiment 2

[0105] Embodiment 2 lozenge of the present invention

[0106] Take Chuan Fritillaria 30g, Ophiopogon japonicus 23g, Trichosanthes 16g, Scutellaria baicalensis 25g, Trichosanthes 34g, Dannanxing 29g, Platycodon grandiflorum 16g, Tianzhuhuang 24g, fat sea 32g, sea clam shell 21g, perilla seed 18g, almond 8g, aster 14g , Coltsfoot flower 30g, mulberry leaves 24g, Tinglizi 29g, Luo Han Guo 19g, cotyledon leaves 17g, Digupi 23g, g, Sijiqing 23g, brocade lantern 36g, green fruit 13g, houttuynia cordata 36g, lung meridian grass 7g, Dabagu 16g, Chuanposhi 27g, Gangmeigen 21g and Tibetan Liwu 38g.

[0107] Its preparation method comprises the following steps:

[0108]In the first step, mix Fritillaria chinensis, Ophiopogon japonicus, Trichosanthes chinensis, Scutellaria baicalensis, Trichosanthes chinensis and Platycodon grandiflorum in the stated proportions, soak in ethanol with an alcohol concentration of 95% that is 6 times the mass of the obtained mixture, and heat to reflux for ...