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Absorbable magnesium alloy staples with antibacterial and anti-inflammatory functions and preparation method thereof

An antibacterial and anti-inflammatory, magnesium alloy technology, applied in medical science, surgery, surgical instruments, etc., can solve the problems of tissue hyperplasia, peeling, non-antibacterial and anti-inflammatory effects, etc., and achieve the effect of slowing down degradation and increasing load capacity

Active Publication Date: 2015-12-30
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, gelatin is a potential excellent carrier capable of loading drugs and copper ions at the same time, but the binding force between gelatin and magnesium alloy is poor, and simple coating is prone to peeling off. How to make gelatin and magnesium alloy tightly combined is the key to effective loading
[0005] To sum up, the traditional titanium alloy or tantalum metal staples are not degradable and can easily cause tissue hyperplasia and other problems. However, the degradable magnesium alloy staples currently studied do not have antibacterial and anti-inflammatory effects, and antibacterial copper ions and anti-inflammatory drugs are loaded into the Magnesium alloy staples can achieve antibacterial and anti-inflammatory purposes, but loading technology and release speed control methods are urgent problems to be solved

Method used

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  • Absorbable magnesium alloy staples with antibacterial and anti-inflammatory functions and preparation method thereof

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Effect test

Embodiment 1

[0030] The absorbable magnesium alloy staple with antibacterial and anti-inflammatory functions of the present invention consists of a core of pure magnesium wire with a porous ceramic layer on the surface, an intermediate layer loaded with ibuprofen anti-inflammatory drugs and copper ions with gelatin as a carrier, and is degradable. The composition of the outer surface layer of polylactic acid, its specific preparation process is as follows:

[0031] 1) Drawing pure magnesium into a wire with a diameter of 0.3mm;

[0032] 2) Perform micro-arc oxidation treatment on the magnesium wire. The main components of the electrolyte are 10g / L sodium silicate, 2g / LNaOH and 8g / L hydroxyapatite nanoparticles, the magnesium wire is immersed in it, and a voltage of 420V is applied for 15 minutes of micro-arc oxidation treatment to make it A layer of porous ceramic layer rich in magnesium oxide, magnesium silicate and hydroxyapatite is formed on the surface in situ. The average micropore s...

Embodiment 2

[0040] Absorbable magnesium alloy staples with antibacterial and anti-inflammatory functions are composed of an AZ31B magnesium alloy wire core with a porous ceramic layer on the surface, a middle layer loaded with nabumetone and copper ions on the gelatin carrier, and an outer surface of degradable polylactic acid. Layer composition, the specific preparation process is as follows:

[0041] 1) AZ31B magnesium alloy is drawn into a wire with a diameter of 0.5mm;

[0042] 2) Phosphating the surface of the magnesium alloy wire, the solution is NH 4 h 2 PO 4 120g / L, (NH 4 ) 2 SO 3 ·H 2 O30g / L, ammoniacal liquor (30%) 6mL / L, generate the porous ceramic layer based on the phosphate of magnesium, the average pore size of ceramic layer is 10 μ m, and average layer thickness is 30 μ m;

[0043] 3) Weigh 5mg of nabumetone and dissolve it in 100ml of dichloromethane solution;

[0044] 4) Dissolve 3g of gelatin in 1L of 80°C distilled water to obtain a gelatin solution, add an app...

Embodiment 3

[0050] The absorbable magnesium alloy staple with antibacterial and anti-inflammatory functions consists of a WE43 magnesium alloy wire core with a porous ceramic layer on the surface, a middle layer loaded with acemetacin and copper ions on the gelatin carrier, and a degradable PLGA surface. Surface composition, its specific preparation process is as follows:

[0051] 1) Drawing WE43 magnesium alloy into a wire with a diameter of 0.5mm;

[0052] 2) Perform micro-arc oxidation treatment on the magnesium wire. The main components of the electrolyte are 10g / L sodium silicate and 2g / LNaOH. The magnesium wire is immersed in it, and a voltage of 380V is applied for 10 minutes of micro-arc oxidation treatment, so that a layer rich in magnesium oxide is formed on the surface in situ. , Magnesium silicate porous ceramic layer, the average micropore size of the ceramic layer is 8 μm, and the average layer thickness is 20 μm;

[0053] 3) Weigh 10 mg of acemetacin and dissolve it in 15...

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Abstract

The invention relates to an absorbable magnesium alloy staple having antibiosis and anti-inflammation functions, and a making method thereof. The staple is composed of a pure magnesium or magnesium alloy wire core with the surface containing a porous ceramic layer, an intermediate functional layer loaded with anti-inflammation medicines and copper ions with gelatin as a carrier, and a degradable high-molecular external surface layer. The copper ions and the anti-inflammation medicines are effectively loaded on the surface of the wire with gelatin as the carrier by adopting an electrophoresis-electrodeposition process, and the external surface layer of the staple is a degradable high-molecular layer having a protection effect. The staple can slowly release the copper ions having a sterilizing effect and the anti-inflammation medicines having an anti-inflammation effect in the use process. Additionally, the synergistic effect between the intermediate functional layer with the gelatin as the carrier and the external degradable high-molecular layer realizes the effective control of the medicine release rate and the staple degradation speed. The staple can be widely applied to the stitching or inosculation of the intestine, the stomach and other human body different positions, and has a wide application prospect.

Description

technical field [0001] The invention relates to an absorbable magnesium alloy staple with antibacterial and anti-inflammatory functions and a preparation method thereof. The staple can be completely degraded and absorbed in the environment of the body, and can slowly release anti-inflammatory drugs with anti-inflammatory effects and sterilization during the degradation process. At the same time, the staples have the necessary acid or alkali corrosion resistance in the early postoperative stage, and can resist the early corrosion damage of the strong acid environment in the stomach. It is suitable for various operations in the human body, especially after digestive tract operations. The utility model is used for anastomosis and suturing of wounds, and belongs to the technical field of surgical anastomosis and suturing instruments. Background technique [0002] Staples are currently widely used for suturing surgical wounds. Traditional staples are made of titanium alloys or ta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10
Inventor 储成林李旋刘珣白晶郭超薛烽林萍华
Owner SOUTHEAST UNIV
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