Polyester catalyst with antibacterial and osteogenic activity and preparation method thereof

Abstract

The invention provides a polyester catalyst with antibacterial and osteogenic activity, which is prepared by the following steps: carrying out pre-polycondensation on dicarboxylic acid or dibasic ester and excessive dihydric alcohol to fully react to form a prepolymer; and carrying out transesterification on the prepolymer by using a zinc catalyst, and simultaneously reducing the pressure to continuously remove small molecular byproducts. Compared with the prior art, the invention has the following prominent advantages: (1) the invention provides a novel transesterification catalyst, zinc is an important metal element in a living body, has the characteristics of no toxicity and absorbability, has biological activity and has a promoting effect on proliferation of bone osteoblasts of a human body, and meanwhile, zinc ions have a bactericidal effect, so that the catalyst is a novel transesterification catalyst; and the catalyst is low in cost, can be used massively, and can be applied to the field of biomedicine. And (2) the aliphatic polyester prepared by the invention has the characteristics of degradability and strong safety, and has good market space and value.

Description

technical field [0001] The invention belongs to the technical field of degradable polyester synthesis, specifically relates to a polyester catalyst with antibacterial and osteogenic activity and a preparation method, and is a novel transesterification catalyst and polyester synthesis method for degradable polyester. Background technique [0002] Degradable materials are a class of products that can be degraded into small molecules that are harmless to the environment under the action of factors such as light, heat, oxygen, water, and microorganisms in the natural environment. At present, countries all over the world are vigorously carrying out research on such products. In the current research on degradable materials, polyester degradable materials occupy an important position. Since the aliphatic polyester polymer chain contains ester bonds, it is easily hydrolyzed or degraded by microorganisms into small molecules such as water and carbon dioxide. For example, the surgic...

AI Technical Summary

Problems solved by technology

When titanium series elements are used as catalysts, the catalytic activity is very high, but titanium series catalysts can accelerate the aging of polyester materials, and make the product yellow, which affects the use. Generally, it is necessary to add a stabilizer to stabilize it.

Antimony is toxic, not conducive to environmental protection, and cannot be used in biological materials

The price of germanium series is too expensive, which is not conducive to large-scale application

It is also reported that organic solvents are used as catalysts, because organic solvents are toxic and difficult to remove from the product, thus limiting their application in the biomedical field