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Control method of relative substance and polymer in phenoxymethylpenicillin potassium

A technology of penicillin V and control method, which is applied in the directions of effective components of heterocyclic compounds, pharmaceutical formulations, drug delivery, etc., can solve the problem of high cost, and achieve the effects of stable product quality, low cost and simple control method.

Inactive Publication Date: 2014-11-19
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of microcapsules requires special techniques and instruments, and the cost is high.

Method used

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  • Control method of relative substance and polymer in phenoxymethylpenicillin potassium
  • Control method of relative substance and polymer in phenoxymethylpenicillin potassium
  • Control method of relative substance and polymer in phenoxymethylpenicillin potassium

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Experimental program
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Embodiment Construction

[0032] The present invention will be further illustrated below by way of examples, but the present invention is not limited thereto. For the experimental methods without specific conditions indicated in the following examples, the conventional conditions or the conditions suggested by the manufacturer are usually followed. The percentages not specified below are all percentages by mass.

[0033] The names and quantities of raw and auxiliary materials used are shown in Table 1.

[0034] Table 1

[0035]

[0036]

[0037] See Table 2 for the names and quantities of packaging materials.

[0038] Table 2

[0039]

[0040] The quality standards of finished products are shown in Table 3.

[0041] table 3

[0042]

[0043]

[0044] The operating room and main equipment of each process are shown in Table 4 and Table 5 respectively.

[0045] Table 4

[0046]

[0047] table 5

[0048] process

device name

model

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Multi-directi...

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Abstract

The invention provides a production process of a phenoxymethylpenicillin potassium capsule, and a control method of relative substances and polymers in the production process of phenoxymethylpenicillin capsule. The control method of relative substances and polymers in the production process of phenoxymethylpenicillin capsule has the advantages of simpleness, low cost, stable product quality, and benefit for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a quality control method in the preparation process of penicillins, in particular to a control method for related substances and polymers in penicillin V potassium. Background technique [0002] Penicillin V (penicillin V) is the phenoxymethyl derivative of penicillin G, penicillin V potassium (penicillin V potassium, phenoxymethylpenicillin potassium) is the potassium salt of penicillin V, the chemical name is (2S,5R,6R)-3,3- Dimethyl-7-oxo-6-(2-phenoxyacetylamino)-4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylic acid potassium salt with the formula C 16 h 17 KN 2 o 5 S, the molecular weight is 388.5. Potassium penicillin V is the first natural antibiotic for oral administration in the world. It is also the second naturally occurring β-lactam antibiotic with clinical value after penicillin G. It has been widely used since it was launched in 1953. [0003] Penicillin V is a biosynthetic,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/43A61P31/04A61J3/07
Inventor 周璇
Owner SICHUAN PHARMA