Identification of key proteins based on subcellular localization specificity

Abstract

The invention discloses a key protein identification method based on subcellular localization specificity. The method includes the first step of establishing subcellular localization protein interaction subnets; the second step of measuring confidence levels of protein key scores of all the subcellular localization interaction subnets of all proteins; the third step of calculating key comprehensive scores of all the proteins; the fourth step of outputting the result, wherein all the proteins in a cell are ranked according to the key comprehensive scores, and the ranking result is output. The key protein identification method based on the subcellular localization specificity is high in accuracy and sensitivity in the identification aspect of key proteins.

Description

technical field [0001] The invention belongs to the field of systems biology and relates to a key protein identification method based on subcellular localization specificity. Background technique [0002] As we all know, different proteins have different effects on the life activities of biological organisms, and their importance is also different. Generally speaking, the proteins necessary to maintain the life activities of organisms in the protein interaction network are considered as key proteins. The absence of key proteins leads to cell death or the inability to reproduce. The identification of key proteins can promote the development of drug targeting technology [Note: Drug targets refer to biomacromolecules that have pharmacological functions in the body and can be affected by drugs, such as certain proteins and nucleic acids and other biomacromolecules. Those genes encoding target proteins are also called target genes. Determining in advance the target molecules r...

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However, due to the incompleteness of the structural domain information, the prediction results will be biased

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