Integrated structure of optical fiber provided with label-free optical sensing element on one end face and microfluid

A microfluidic structure and optical sensing technology, applied in the field of biosensors, can solve the problems that no one has proposed the integration of sensing elements and microfluidic channels, and achieve the effect of simple structure, short diffusion distance and less usage

Active Publication Date: 2014-11-26
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But no one has proposed integrating these sensing elements with microfluidic channels

Method used

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  • Integrated structure of optical fiber provided with label-free optical sensing element on one end face and microfluid
  • Integrated structure of optical fiber provided with label-free optical sensing element on one end face and microfluid
  • Integrated structure of optical fiber provided with label-free optical sensing element on one end face and microfluid

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Embodiment 1

[0033] Such as Figure 1 ~ Figure 2 As shown, the present embodiment provides a fiber end-face marker-free optical sensing element and microfluidic integrated structure, including at least:

[0034] microfluidic structure 20;

[0035] At least one end face of the optical fiber 21 has an unmarked optical sensing element 211 , and one end of the optical fiber 21 with an unmarked optical sensing element 211 is inserted into the microfluidic frame.

[0036] As an example, the microfluidic structure 20 at least includes a microfluidic channel 201 , a microfluidic inlet 202 and a microfluidic outlet 203 , and of course, the microfluidic structure 20 also has at least one through hole for inserting an optical fiber. Wherein, the microfluidic structure 20 can be prepared by methods such as mold inversion, laser cutting, and micro-nano processing.

[0037] Further, the shape of the microfluidic channel 201 is cylindrical, polygonal columnar or rounded polygonal columnar. Of course, th...

Embodiment 2

[0046] Such as Figure 3 to Figure 9 As shown, this embodiment provides a method for fabricating an optical fiber end-face marker-free optical sensing element and a microfluidic integrated structure, which at least includes the following steps:

[0047] Such as Figure 3 ~ Figure 6 As shown, step 1) is first performed to form a polymer structure 104 having at least one flat surface, a microfluidic groove 105 and at least one linear groove 106 connected to the microfluidic groove 105 in the flat surface.

[0048] As an example, step 1) consists of the following steps:

[0049] Such as image 3 As shown, step 1-1) is carried out first, a container 101 with a flat bottom is provided, and a solid block 102 with a predetermined shape and at least one line structure 103 connected with the solid block 102 are fixed at the bottom of the container 101 , the size and shape of the line structure 103 is consistent with that of the optical fiber.

[0050] Such as Figure 4 shown, and ...

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Abstract

The invention provides an integrated structure of an optical fiber provided with a label-free optical sensing element on one end face and a microfluid. The structure at least comprises a microfluid structure and at least an optical fiber which is provided with a label-free optical sensing element arranged on one end of the optical fiber. The end, which is provided with the label-free optical sensing element, is inserted into the frame of the microfluid. The structure integrates an optical fiber provided with a label-free optical sensing element and a microfluid, thus has the advantages of simple structure, agility, convenience, good stability, little using amount of biological sample of microfluid chip, short diffusion distance of biomolecule, multichannel parallel detection, and integrated microfluid functions, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the field of biosensors, in particular to a mark-free optical sensing element on the end face of an optical fiber and a microfluidic integrated structure. Background technique [0002] Label-free bio-optical sensing technology has been widely used in biopharmaceutical process monitoring and protein research applications. In order to reduce the amount of biological samples used, reduce the diffusion distance of biomolecules, and multi-channel parallel detection, etc., it is often desirable to integrate sensing components into the channels of the microfluidic chip. At the same time, various other functions and sensing can be integrated on a chip through microfluidic technology. [0003] On the other hand, the combination of label-free bio-optical sensing technology and fiber-optic waveguide has also been paid attention to, which can make the optical path in the sensing system be realized by optical fiber, reduce the complexity a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/01
Inventor 杨天贺晓龙范旭东
Owner SHANGHAI JIAO TONG UNIV
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