Preparation method and application of magnetic diethylstilbestrol molecularly-imprinted polymer

A magnetic molecular imprinting and diethylstilbestrol technology, which is applied in the field of separation and analysis, can solve the problems of increasing sample pretreatment time, reducing the recovery rate of target compounds, affecting analysis efficiency, etc., and achieves fast and simple extraction and separation, strong application value, and improved mass transfer. effect of speed

Active Publication Date: 2014-12-10
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there are many types of solid-phase extraction materials used in food today, they generally have the problem of poor specificity. It is often necessary to increase sample pretreatment steps or further process samples, especially food samples, in order to meet the requirements of analysis and detection, which often It will lead to a decrease in the recovery rate of the target substance, increase the time of sample pretreatment, and affect the analysis efficiency

Method used

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  • Preparation method and application of magnetic diethylstilbestrol molecularly-imprinted polymer
  • Preparation method and application of magnetic diethylstilbestrol molecularly-imprinted polymer
  • Preparation method and application of magnetic diethylstilbestrol molecularly-imprinted polymer

Examples

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Embodiment 1

[0038] Example 1: Preparation of organic-inorganic diethylstilbestrol magnetic molecularly imprinted polymer according to the content of the invention

[0039] The preparation process of diethylstilbestrol magnetic molecularly imprinted polymer is as follows:

[0040] a. Synthesis of Fe by co-precipitation method 3 o 4 particle. 2.0gFeSO 4 ·7H 2 O with 3.9g FeCl 3 ·6H 2 O was placed in a Erlenmeyer flask, 200 mL of deionized water was added, stirred mechanically to dissolve it, and then heated to 60°C under nitrogen protection, 5 mL of ammonia water was added at one time, and the reaction was continued for 1 h with heating and stirring. After the reaction, the black product was separated from the supernatant by using an external magnetic field of a super-strong magnet, and washed repeatedly with deionized water and absolute ethanol until the washing liquid was neutral. The composite was dried in a vacuum oven at 60° C. to constant weight, and the obtained black product ...

Embodiment 2

[0045] Example 2: Characterization of the magnetic molecularly imprinted polymer of diethylstilbestrol prepared in Example 1

[0046] (1) SEM analysis;

[0047] (2) Infrared spectral analysis.

Embodiment 3

[0048] Example 3: Study on the Adsorption Performance of Diethylstilbestrol Magnetic Molecularly Imprinted Polymers

[0049] (1) Adsorption kinetics of magnetically imprinted and non-imprinted polymers on diethylstilbestrol

[0050] In order to investigate the adsorption rate of the magnetic molecularly imprinted polymer prepared by the present invention to template molecules, the variation trend of the adsorption amount (Q) of 50 mg magnetically imprinted and non-imprinted polymers to 5 mL100 mg / L diethylstilbestrol was tested under different adsorption times, the result Such as figure 2 As shown, although the adsorption equilibrium time of magnetic non-imprinted polymers is faster than that of imprinted polymers, the saturated adsorption capacity is relatively small, and the adsorption capacity of magnetically imprinted polymers basically reaches equilibrium in about 10 minutes, which shows that magnetically imprinted polymers have a strong effect on template molecules. Wi...

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Abstract

The invention relates to the technical fields of separation and analysis and particularly discloses a preparation method and application of a magnetic diethylstilbestrol molecularly-imprinted polymer based on an organic-inorganic hybridizing technology. The preparation method comprises the steps of preparing ferroferric oxide particles by using a coprecipitation method; preparing silanized ferroferric oxide by using a stober method; preparing an organic and inorganic hybrid magnetic diethylstilbestrol molecularly-imprinted polymer by using a bulk polymerization method; and grinding the polymer, sieving, adding an eluent to extract and elute, and then, drying to obtain the magnetic diethylstilbestrol molecularly-imprinted polymer. A target product, namely diethylstilbestrol, can be rapidly combined on the surface of the magnetic diethylstilbestrol molecularly-imprinted polymer synthesized by using the preparation method and can be rapidly separated from a reaction system under the action of an external magnetic field, so that the aim of efficiently separating a trace amount of diethylstilbestrol from a complex matrix at high specificity is achieved, and the sample pretreatment efficiency is greatly increased.

Description

(1) Technical field [0001] The invention relates to the technical field of separation and analysis, in particular to a preparation method and application of a diethylstilbestrol magnetic molecularly imprinted polymer based on an organic-inorganic hybrid technology. (2) Background technology [0002] Due to the excessive use of synthetic estrogens to promote animal growth, estrogens are abundant in the environment. Currently, the estrogen residues found in fish and poultry are also present in other foods of animal origin, such as eggs and milk. The estrogens present in the environment play the role of endocrine disruptors, which will have a great impact on the reproductive system of animals and humans, and this impact is often irreversible. As a widely used estrogen, diethylstilbestrol can interfere with the endocrine function of organisms by simulating or antagonizing normal endogenous hormones, and has potential carcinogenicity. It is stipulated that diethylstilbestrol an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/06C08F230/08C08F2/44C08K9/10C08K3/22C08J9/26B01J20/26B01J20/28B01J20/30G01N30/06
Inventor 何金兴李迎秋李龙飞崔一笑
Owner QILU UNIV OF TECH
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