Functions and application of responsive to centrifugal force and shear stress gene 1 (RECS1) to treatment of restenosis after vascular injury

Abstract

The invention discloses functions and application of responsive to centrifugal force and shear stress gene 1 (RECS1) to treatment of restenosis after vascular injury. An RECS1 knockout mouse and a wild type mouse are taken as experimental subjects, and detection on mouse internal membrane regeneration, vessel wall cell proliferation level and smooth muscle cell phenotype transformation is carried out by a vascular injury model. Detection results prove that by virtue of RECS1 knockout, internal membrane regeneration and cell proliferation can be obviously inhibited, and smooth muscle cells are inhibited to be transformed into synthetic phenotype from contractile phenotype. Therefore, the functions of the RECS1 to the restenosis after vascular injury are mainly embodied in that internal membrane regeneration, cell proliferation and smooth muscle cell phenotype transformation are promoted by the RECS1. Aiming at the functions of the RECS1, the RECS1 can be used as a drug target for screening medicines for preventing, relieving and / or treating the disease of restenosis after vascular injury; an inhibitor of the RECS1 can be used for preparing medicines and arterial stents for preventing, relieving and / or treating the restenosis after vascular injury.

Description

[0001] technical field

[0002] The invention belongs to the field of gene function and application, and specifically relates to the function and application of a centrifugal force and shear stress response gene 1 (responsive to centrifugal force and shear stress gene 1, RECS1) in the treatment of restenosis after vascular injury, specifically RECS1 Application in the preparation of drugs for preventing, alleviating and / or treating restenosis after vascular injury. Background technique

[0003] With the change of dietary structure and the aging process of the population, atherosclerotic occlusive lesions are increasing year by year and have become one of the main causes of death in our country. Neointimal formation is a key factor in atherosclerosis (AS), pulmonary hypertension, restenosis (RS) after percutaneous coronary intervention (PCI), post-transplant arterial disease, and pulmonary hypertension. Pathological process common to diseases. Vascular intimal neogenesis is...

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